Changes of urinary phospholipids in the chronic kidney disease patients

doi:10.3109/1354750X.2013.837100

CORC > 北京大学 > 化学与分子工程学院

	Changes of urinary phospholipids in the chronic kidney disease patients
	Yang, Wen-Ling ; Bai, Qiong ; Li, Dan-Dan ; Ta-La, A. ; Wang, Song ; Zhao, Rong-Sheng ; Nie, Hong-Gang ; Zhang, Ai-Hua ; Wang, Tao ; Fan, Min-Hua
刊名	biomarkers
	2013
关键词	Chronic kidney disease HPLC-ESI-MS/MS metabolomics urinary phospholipids CHRONIC-RENAL-FAILURE MASS-SPECTROMETRY CHROMATOGRAPHY METABONOMICS INJURY QUANTIFICATION IDENTIFICATION IONIZATION BIOMARKERS OBESITY
DOI	10.3109/1354750X.2013.837100
英文摘要	Objective: To evaluate whether urinary phospholipids could be regarded as biomarkers of chronic kidney disease. Materials and methods: Thirteen healthy volunteers and 26 consecutive chronic kidney disease patients were included. Urinary phospholipids were quantified by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Results: Urinary phosphatidylcholines concentrations (PC 16:0/16:0, 16:0/22:3, 16:0/18:1 and 16:0/18:2) were significantly higher both in glomerulonephritis group (all p<0.001) and in tubulointerstitial injury group (all p < 0.05) than in healthy control group. Meanwhile, sphingomyelin concentrations (SM 18:1/16:0 and 18:1/18:0) in glomerulonephritis group were significantly higher than those in healthy control group (all p<0.001). Urinary PCs and SMs were positively correlated with proteinuria but negatively correlated with serum albumin. Meanwhile, PCs were positively correlated with serum creatinine. Conclusion: Our work first demonstrated that urinary phospholipids might be biomarkers for the chronic kidney disease patients. Increased urinary phospholipids in chronic kidney disease patients might result from proteinuria, damaged kidney function or proteinuria induced hypoalbuminemia or lipotoxicity.; Biotechnology & Applied Microbiology; Toxicology; SCI(E); PubMed; 2; ARTICLE; 7; 601-606; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/161378]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, Wen-Ling,Bai, Qiong,Li, Dan-Dan,et al. Changes of urinary phospholipids in the chronic kidney disease patients[J]. biomarkers,2013.
APA	Yang, Wen-Ling.,Bai, Qiong.,Li, Dan-Dan.,Ta-La, A..,Wang, Song.,...&Fan, Min-Hua.(2013).Changes of urinary phospholipids in the chronic kidney disease patients.biomarkers.
MLA	Yang, Wen-Ling,et al."Changes of urinary phospholipids in the chronic kidney disease patients".biomarkers (2013).