A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for   wound healing

doi:10.1016/j.carbpol.2010.07.013

CORC > 北京大学 > 化学与分子工程学院

	A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing
	Yang, Chao ; Xu, Ling ; Zhou, Ying ; Zhang, Xiangmei ; Huang, Xin ; Wang, Min ; Han, Ye ; Zhai, Maolin ; Wei, Shicheng ; Li, Jiuqiang
刊名	碳水化合物聚合物
	2010
关键词	Gelatin Carboxymethyl chitosan Hydrogel Radiation crosslinking Wound healing ELECTRON-BEAM IRRADIATION HUMAN-SKIN COLLAGENASE CROSS-LINKING CHITIN DEGRADATION CHITOSAN/ALGINATE BIOMATERIALS DERIVATIVES FIBROBLAST PRECURSOR
DOI	10.1016/j.carbpol.2010.07.013
英文摘要	A series of hydrogels were fabricated from an aqueous solution of gelatin and carboxymethyl chitosan (CM-chitosan) by radiation-induced-crosslinking at ambient temperature. Several physicochemical and biological properties of the hydrogels were investigated to evaluate their potential as wound healing materials. By increasing the CM-chitosan content in the hybrid hydrogels, their swelling ability increased significantly, while the compressive modulus decreased. The miscibility between gelatin and CM-chitosan molecules led to a semi-interpenetrate network after crosslinking. Observed by SEM, scaffolds with a homogeneous interconnected pore structure were obtained after lyophilizing the hydrogels. The enzyme degradation rate of the hydrogels was controlled by adjusting the procedure, which could be matched to the healing rate of the wound. Furthermore, the gelatin/CM-chitosan hydrogels promoted cell attachment and rapid growth of fibroblasts on the material. Due to the high water absorption capacity, a similar compressive modulus with soft tissue, controllable biodegradation, and excellent biocompatibility, the gelatin/CM-chitosan hybrid hydrogels have potential as skin scaffolds and wound healing materials. (C) 2010 Elsevier Ltd. All rights reserved.; Chemistry, Applied; Chemistry, Organic; Polymer Science; SCI(E); EI; 42; ARTICLE; 4; 1297-1305; 82
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/154798]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Yang, Chao,Xu, Ling,Zhou, Ying,et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing[J]. 碳水化合物聚合物,2010.
APA	Yang, Chao.,Xu, Ling.,Zhou, Ying.,Zhang, Xiangmei.,Huang, Xin.,...&Li, Jiuqiang.(2010).A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing.碳水化合物聚合物.
MLA	Yang, Chao,et al."A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing".碳水化合物聚合物 (2010).