Structural study and preliminary biological evaluation on the collagen   hydrogel crosslinked by gamma-irradiation

doi:10.1002/jbm.a.34243

CORC > 北京大学 > 化学与分子工程学院

	Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation
	Zhang, Xiangmei ; Xu, Ling ; Huang, Xin ; Wei, Shicheng ; Zhai, Maolin
刊名	journal of biomedical materials research part a
	2012
关键词	collagen hydrogel radiation crosslinking radiation effect biodegradation MECHANICAL-PROPERTIES RAY IRRADIATION UV-IRRADIATION I COLLAGEN RADIATION LINKING GELATIN FILMS GLUTARALDEHYDE MODEL
DOI	10.1002/jbm.a.34243
英文摘要	Under gamma-irradiation, concentrated collagen solutions yielded collagen hydrogels and liquid products. The molecular structure of collagen hydrogels and the source of the liquid products were studied. Furthermore, preliminary biological properties of the hydrogels were investigated. The results revealed that crosslinking occurred to form collagen hydrogel and the crosslinking density increased with the increasing of the absorbed dose, and the collagen hydrogels showed enhanced mechanical properties. Meanwhile, collagen underwent radiation degradation and water was squeezed out from hydrogel by contraction of hydrogel, yielding liquid products. Collagen hydrogels induced by gamma-irradiation maintained the backbone structure of collagen, and tyrosine partially involved in crosslinking. The irradiated collagen hydrogels have higher denatured temperature, can promote fibroblasts proliferation, and their degradation rate in vivo depended on the absorbed dose. The comprehensive results suggested that the collagen hydrogels prepared by radiation crosslinking preserved the triple helical conformation, possessed improved thermal stability and mechanical properties, excellent biocompatibility, which is expected to favor its application as biomaterials. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:29602969, 2012.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309063400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; PubMed; 12; ARTICLE; 11; 2960-2969; 100A
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/153975]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Zhang, Xiangmei,Xu, Ling,Huang, Xin,et al. Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation[J]. journal of biomedical materials research part a,2012.
APA	Zhang, Xiangmei,Xu, Ling,Huang, Xin,Wei, Shicheng,&Zhai, Maolin.(2012).Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation.journal of biomedical materials research part a.
MLA	Zhang, Xiangmei,et al."Structural study and preliminary biological evaluation on the collagen hydrogel crosslinked by gamma-irradiation".journal of biomedical materials research part a (2012).