Acid-labile, thermoresponsive (meth)acrylamide polymers with pendant   cyclic acetal moieties

doi:10.1002/pola.22751

CORC > 北京大学 > 化学与分子工程学院

	Acid-labile, thermoresponsive (meth)acrylamide polymers with pendant cyclic acetal moieties
	Huang, Xiao-Nan ; Du, Fu-Sheng ; Zhang, Bo ; Zhao, Ing-Yi ; Li, Zi-Chen
刊名	journal of polymer science part a polymer chemistry
	2008
关键词	acid-labile cyclic acetal pH-sensitive radical polymerization salt effect stimuli-sensitive polymers thermoresponsive water-soluble polymers CRITICAL SOLUTION TEMPERATURE BIODEGRADABLE THERMOSENSITIVE POLYMERS N-ISOPROPYLACRYLAMIDE COPOLYMERS PHASE-TRANSITION SIDE-GROUPS POLY(N-ISOPROPYLACRYLAMIDE) CHAINS RESPONSIVE POLYMERS HOFMEISTER SERIES AQUEOUS-SOLUTIONS DRUG-DELIVERY
DOI	10.1002/pola.22751
英文摘要	Acid-labile, thermoresponsive polymers with pendant six-membered cyclic acetal groups were prepared by radical polymerization of two monomers, N-(2,2-dimethyl-1,3-dioxan-5-yl) methacrylamide (NDMM) and N-(2,2-dimethyl-1,3-dioxan-5-yl) acrylamide (NDMA). The aqueous solution properties of the polymers, PNDMM and PNDMA, were studied by turbidimetry, H-1 NMR, fluorescence, and DSC measurements. It is found that both polymers show sensitive and reversible phase transitions with distinct lower critical solution temperatures (LCST). Below their LCSTs, there are still some polymer aggregates as evidenced by measurements of pyrene excitation spectra and urea effects on the cloud points (CP) of polymers. The salting effect of six inorganic sodium salts on the phase transition behavior of PNDMM was investigated by turbidimetric approach. The salting-out to salting-in effect is in the order of SO42- > F- > Cl- > Br- > I- > SCN-, following the Hofmeister's series. pH-dependent hydrolysis of PNDMM and PNDMA was studied by turbidimetric and H-1 NMR methods. They are both pH-sensitive and their hydrolysis rates significantly increase with decreasing pH value. The CP of PNDMM gradually increases with the acid-triggered hydrolysis of the acetal groups and the hydrolyzed polymer with similar to 30% hydrolysis degree does not show thermally induced phase transition. (c) 2008 Wiley Periodicals, Inc.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000257153500006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Polymer Science; SCI(E); EI; 16; ARTICLE; 13; 4332-4343; 46
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/151476]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Huang, Xiao-Nan,Du, Fu-Sheng,Zhang, Bo,et al. Acid-labile, thermoresponsive (meth)acrylamide polymers with pendant cyclic acetal moieties[J]. journal of polymer science part a polymer chemistry,2008.
APA	Huang, Xiao-Nan,Du, Fu-Sheng,Zhang, Bo,Zhao, Ing-Yi,&Li, Zi-Chen.(2008).Acid-labile, thermoresponsive (meth)acrylamide polymers with pendant cyclic acetal moieties.journal of polymer science part a polymer chemistry.
MLA	Huang, Xiao-Nan,et al."Acid-labile, thermoresponsive (meth)acrylamide polymers with pendant cyclic acetal moieties".journal of polymer science part a polymer chemistry (2008).