Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine)   Dendronized Poly(2-hydroxyethyl) Methacrylate

doi:10.1021/ma1000783

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine) Dendronized Poly(2-hydroxyethyl) Methacrylate
	Gao, Min ; Jia, Xinru ; Li, Yan ; Liang, Dehai ; Wei, Yen
刊名	macromolecules
	2010
关键词	CRITICAL SOLUTION TEMPERATURES BIOMEDICAL APPLICATIONS BLOCK-COPOLYMERS POLYMERS DELIVERY ASSOCIATION DERIVATIVES DENDRIMERS DRUG GELS
DOI	10.1021/ma1000783
英文摘要	The first and second generation poly(amidoamine) dendronized poly(2-hydroxylethyl) methacrylate (PGn-macro (n = 1, 2)) were synthesized by the macromonomer approach. The structures and molecular weights of the obtained polymers were characterized by (1)H NM R. FTIR, and GPC. UV-vis turbidity measurements revealed that all the resultant polymers were thermo-responsive, exhibiting the LCSTs in the range of 16-33 degrees C. The polymers also showed pH sensitive for the existence of the tertiary amino groups in the interior of the pendent dendrons. It was found that the generation of the dendrons, the molecular weights of the polymers, the concentrations, and the pi-is showed great influence on the lower critical solution temperatures (LCSTs) of the polymer solutions. The higher LCST could be achieved either by increasing the generation of the dendrons or by decreasing the molecular weight. The dilute polymer solution with lower pH displayed the higher LCST. For example, the LCST of PG I-macro solution increased significantly with the pH decreased below 7.0, but the decrease of LCST was much slower at pH >= 7.0. DLS experiments at variable temperatures demonstrated that the polymer chains spontaneously aggregated to form large size particles as increasing the temperature above LCST due to the dehydration of the peripheral butylamide groups and the enhanced hydrophobic interactions. The morphology of aggregates was directly visualized by optical microscopy, and uniform spherical aggregates with the diameter of 3-7 mu m were observed.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000277274200041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Polymer Science; SCI(E); EI; 24; ARTICLE; 9; 4314-4323; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/151190]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Gao, Min,Jia, Xinru,Li, Yan,et al. Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine) Dendronized Poly(2-hydroxyethyl) Methacrylate[J]. macromolecules,2010.
APA	Gao, Min,Jia, Xinru,Li, Yan,Liang, Dehai,&Wei, Yen.(2010).Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine) Dendronized Poly(2-hydroxyethyl) Methacrylate.macromolecules.
MLA	Gao, Min,et al."Synthesis and Thermo-/pH- Dual Responsive Properties of Poly(amidoamine) Dendronized Poly(2-hydroxyethyl) Methacrylate".macromolecules (2010).