Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus | |
Lin, Shixian ; Yan, Huan ; Li, Lin ; Yang, Maiyun ; Peng, Bo ; Chen, She ; Li, Wenhui ; Chen, Peng R. | |
刊名 | angewandte chemie international edition
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2013 | |
关键词 | click chemistry hepatitisD virus site-specific engineering unnatural amino acids B-VIRUS GENETIC-CODE DELTA VIRUS MAMMALIAN-CELLS PROTEINS PARTICLES INFECTION DISEASE DOMAIN ENTRY |
DOI | 10.1002/anie.201305787 |
英文摘要 | Precise virus labeling: The genetic code expansion strategy was coupled with an engineered virus assembly process in human hepatocytes to produce intact human hepatitis D virus (HDV) bearing a genetically encoded unnatural amino acid. The resultant HDV virions, with one type of five different pyrrolysine analogues introduced site-specifically into virus surface proteins, exhibited near wild-type viability and infectivity. Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.; Chemistry, Multidisciplinary; SCI(E); EI; 0; ARTICLE; 52; 13970-13974; 52 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/150692] ![]() |
专题 | 化学与分子工程学院 生命科学学院 |
推荐引用方式 GB/T 7714 | Lin, Shixian,Yan, Huan,Li, Lin,et al. Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus[J]. angewandte chemie international edition,2013. |
APA | Lin, Shixian.,Yan, Huan.,Li, Lin.,Yang, Maiyun.,Peng, Bo.,...&Chen, Peng R..(2013).Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus.angewandte chemie international edition. |
MLA | Lin, Shixian,et al."Site-Specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus".angewandte chemie international edition (2013). |
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