Probing the Anticancer Mechanism of (-)-Ainsliatrimer A through Diverted   Total Synthesis and Bioorthogonal Ligation

doi:10.1002/anie.201407225

CORC > 北京大学 > 化学与分子工程学院

	Probing the Anticancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation
	Li, Chao ; Dong, Ting ; Li, Qiang ; Lei, Xiaoguang
刊名	angewandte chemie international edition
	2014
关键词	antitumor agents bioorganic chemistry bioorthogonal ligation diverted total synthesis target identification ACTIVATED RECEPTOR-GAMMA NATURAL-PRODUCTS TARGET IDENTIFICATION BIOMIMETIC SYNTHESES PEROXISOME PROLIFERATORS QUINONE METHIDE MOLECULES CHEMISTRY CYCLOOXYGENASE-2 EXPRESSION
DOI	10.1002/anie.201407225
英文摘要	Herein, we report an efficient approach for exploring the novel anticancer mechanism of (-)-ainsliatrimer A, a structurally complex and unique trimeric sesquiterpenoid, through a combined strategy of diverted total synthesis (DTS) and bioorthogonal ligation (TQ ligation), which allowed us to visualize the subcellular localization of this natural product in live cells. Further biochemical studies facilitated by pretarget imaging revealed that PPAR gamma, a nucleus receptor, was a functional cellular target of ainsliatrimer A. We also confirmed that the anticancer activity of ainsliatrimer A was caused by the activation of PPAR gamma.; Chemistry, Multidisciplinary; SCI(E); EI; 1; ARTICLE; xglei@pku.edu.cn; 45; 12111-12115; 53
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150374]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Li, Chao,Dong, Ting,Li, Qiang,et al. Probing the Anticancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation[J]. angewandte chemie international edition,2014.
APA	Li, Chao,Dong, Ting,Li, Qiang,&Lei, Xiaoguang.(2014).Probing the Anticancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation.angewandte chemie international edition.
MLA	Li, Chao,et al."Probing the Anticancer Mechanism of (-)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation".angewandte chemie international edition (2014).