Synthesis and in vitro evaluation of three (99m)Tc-labeled   hydroxamamide-based ligands as markers for hypoxic cells

doi:10.1016/j.apradiso.2008.12.003

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells
	Chu, Taiwei ; Xu, Hong ; Yang, Zhi ; Wang, Xiangyun
刊名	应用辐射与同位素
	2009
关键词	(99m)Tc complex Hypoxia marker Lipophilicity Hydroxamamide Labeling TUMOR HYPOXIA TC-99M RADIOPHARMACEUTICALS TETRADENTATE LIGANDS
DOI	10.1016/j.apradiso.2008.12.003
英文摘要	Three new hydroxamamide derivatives with different lipophilicity, N'-hydroxy-N-methyl-3-(4-nitro-1H-imidazol-1-yl)propanamidine, N-butyl-N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)propanamidine, and N'-hydroxy-3-(4-nitro-1H-imidazol-1-yl)-N-octadecyl propanamidine were easily synthesized and labeled with technetium-99m as markers for hypoxic cells. The results of in vitro experiment indicate that the accumulation of three (99m)Tc-complexes steadily increases with time in hypoxic cells, but fluctuates with time and has no fixed trend in aerobic cells; the complex with higher lipophilicity shows more uptake in cells; and the effect of lipophilicity of the (99m)Tc-complexes on the hypoxic/aerobic difference can be neglected. (C) 2009 Elsevier Ltd. All rights reserved.; Chemistry, Inorganic & Nuclear; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging; SCI(E); EI; PubMed; 4; ARTICLE; 4; 590-593; 67
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/150138]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Chu, Taiwei,Xu, Hong,Yang, Zhi,et al. Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells[J]. 应用辐射与同位素,2009.
APA	Chu, Taiwei,Xu, Hong,Yang, Zhi,&Wang, Xiangyun.(2009).Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells.应用辐射与同位素.
MLA	Chu, Taiwei,et al."Synthesis and in vitro evaluation of three (99m)Tc-labeled hydroxamamide-based ligands as markers for hypoxic cells".应用辐射与同位素 (2009).