Synthesis and immunomodulatory activity of [60]fullerene-tuftsin   conjugates

doi:10.1016/j.biomaterials.2011.09.022

CORC > 北京大学 > 化学与分子工程学院

	Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates
	Xu, Yingying ; Zhu, Jiadan ; Xiang, Kun ; Li, Yuankai ; Sun, Ronghua ; Ma, Jie ; Sun, Hongfang ; Liu, Yuanfang
刊名	biomaterials
	2011
关键词	Fullerene C(60) Tuftsin Peritoneal macrophages Phagocytosis Chemotaxis MHC II SOLUBLE FULLERENE DERIVATIVES MURINE PERITONEAL-MACROPHAGES VACCINE-DELIVERY TUFTSIN PHAGOCYTOSIS ANALOGS ACID C-60(OH)(X) CHEMOTAXIS INHIBITION
DOI	10.1016/j.biomaterials.2011.09.022
英文摘要	Immunomodulating peptide tuftsin (Thr-Lys-Pro-Arg) was covalently conjugated to fullerene C(60) by two different ways to prepare NH(2)-tuftsin-C(60) and C(60)-tuftsin-COOH. The two new compounds were intensively characterized. The synthetic C(60)-tuftsin conjugates were assayed for their stability against leucine aminopeptidase degradation. And the immunostimulating activities to murine peritoneal macrophages were investigated in vitro. Compared with the natural tuftsin, significant enhancement of phagocytosis, chemotaxis activities and major histocompatibility complex class II (MHC II) molecule expression were observed in macrophages stimulated by both of the conjugates. The two conjugates also exhibit complete resistance to enzymatic hydrolysis, and they are non-toxic to macrophages in the tested concentrations. On all accounts, these results suggest that the C(60)-tuftsin conjugates can be used as potential candidates of immunomodulators and vaccine adjuvants. (C) 2011 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000296821800039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; PubMed; 10; ARTICLE; 36; 9940-9949; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149974]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Xu, Yingying,Zhu, Jiadan,Xiang, Kun,et al. Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates[J]. biomaterials,2011.
APA	Xu, Yingying.,Zhu, Jiadan.,Xiang, Kun.,Li, Yuankai.,Sun, Ronghua.,...&Liu, Yuanfang.(2011).Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates.biomaterials.
MLA	Xu, Yingying,et al."Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates".biomaterials (2011).