Bioimaging and toxicity assessments of near-infrared upconversion   luminescent NaYF4:Yb,Tm nanocrystals

doi:10.1016/j.biomaterials.2011.08.038

CORC > 北京大学 > 化学与分子工程学院

	Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals
	Zhou, Jia-Cai ; Yang, Zheng-Lin ; Dong, Wei ; Tang, Ruo-Jin ; Sun, Ling-Dong ; Yan, Chun-Hua
刊名	biomaterials
	2011
关键词	Near-infrared emission NaYF4:Yb,Tm nanocrystals Bioimaging Toxicity assessments In vitro In vivo NEMATODE CAENORHABDITIS-ELEGANS IN-VIVO FLUORESCENT NANOPARTICLES NAYF4 NANOPARTICLES NANOPHOSPHORS CELLS PHOTOLUMINESCENCE BIOCOMPATIBILITY BEHAVIOR MODEL
DOI	10.1016/j.biomaterials.2011.08.038
英文摘要	In vitro or in vivo bioimaging utilizing the upconversion (UC) luminescence of rare earth fluoride nanocrystals (NCs) has attracted much attention, especially for Yb3+/Tm3+ doped NCs with a near-infrared (NIR) UC emission at 800 nm. Herein, water-soluble NaYF4:Yb,Tm NCs with strong NIR UC emission were synthesized with a solvothermal method. In vitro and in vivo bioimaging and toxicity assessments were carried out with HeLa cell and Caenorhabditis elegans (C. elegans) cases, respectively. NaYF4:Yb,Tm NCs afforded an efficient NIR image of the HeLa cells with an incubation concentration of 10 mu g mL(-1), and CCK-8 assay revealed a low cytotoxicity. Fed with Escherichia coli (E. coli) and NCs together, the C elegans showed a NIR image in the gut from the pharynx to the anus. Further, these NCs could be excreted out when those worms were then fed with only E. Coli Toxicity studies were further addressed with protein expression, life span, egg production, egg viability, and growth rate of the worms in comparison with those of the intact ones. The feeding of rare earth fluoride NCs with a dose of 100 mu g does not arise obvious toxicity effect from the growth to procreation. The in vitro and in vivo studies confirm that NaYF4:Yb,Tm NCs could be served as an excellent NIR emission bioprobe with low toxicity. (C) 2011 Elsevier Ltd. All rights reserved.; Engineering, Biomedical; Materials Science, Biomaterials; SCI(E); EI; PubMed; 101; ARTICLE; 34; 9059-9067; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149930]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Zhou, Jia-Cai,Yang, Zheng-Lin,Dong, Wei,et al. Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals[J]. biomaterials,2011.
APA	Zhou, Jia-Cai,Yang, Zheng-Lin,Dong, Wei,Tang, Ruo-Jin,Sun, Ling-Dong,&Yan, Chun-Hua.(2011).Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals.biomaterials.
MLA	Zhou, Jia-Cai,et al."Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals".biomaterials (2011).