Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile   Phase for LC-ESI-MS Analysis of Small Molecules and Proteins

doi:10.1007/s13361-012-0385-z

CORC > 北京大学 > 化学与分子工程学院

	Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins
	Zhou, Zhigui ; Zhang, Jialing ; Xing, Jiawei ; Bai, Yu ; Liao, Yiping ; Liu, Huwei
刊名	journal of the american society for mass spectrometry
	2012
关键词	Membrane Remover Trifluoroacetic acid Liquid chromatography Mass spectrometry IONIZATION MASS-SPECTROMETRY ELECTROSPRAY-IONIZATION SIGNAL ENHANCEMENT BIPOLAR MEMBRANES SENSITIVITY
DOI	10.1007/s13361-012-0385-z
英文摘要	We developed a "continuous" trifluoroacetic acid (TFA) remover based on electrodialysis with bipolar membrane for online coupling of liquid chromatography (LC) and electrospray ionization mass spectrometry (ESI-MS) using TFA containing mobile phase. With the TFA remover as an interface, the TFA anion in the mobile phase was removed based on electrodialysis mechanism, and meanwhile, the anion exchange membrane was self-regenerated by the hydroxide ions produced by the bipolar membrane. So the remover could continuously work without any additional regeneration process. The established LC-TFA remover-MS system has been successfully applied for the qualitative and quantitative analysis of small molecules as well as proteins.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305231700016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy; SCI(E); EI; PubMed; 0; ARTICLE; 7; 1289-1292; 23
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149888]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhou, Zhigui,Zhang, Jialing,Xing, Jiawei,et al. Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins[J]. journal of the american society for mass spectrometry,2012.
APA	Zhou, Zhigui,Zhang, Jialing,Xing, Jiawei,Bai, Yu,Liao, Yiping,&Liu, Huwei.(2012).Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins.journal of the american society for mass spectrometry.
MLA	Zhou, Zhigui,et al."Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins".journal of the american society for mass spectrometry (2012).