Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins | |
Zhou, Zhigui ; Zhang, Jialing ; Xing, Jiawei ; Bai, Yu ; Liao, Yiping ; Liu, Huwei | |
刊名 | journal of the american society for mass spectrometry
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2012 | |
关键词 | Membrane Remover Trifluoroacetic acid Liquid chromatography Mass spectrometry IONIZATION MASS-SPECTROMETRY ELECTROSPRAY-IONIZATION SIGNAL ENHANCEMENT BIPOLAR MEMBRANES SENSITIVITY |
DOI | 10.1007/s13361-012-0385-z |
英文摘要 | We developed a "continuous" trifluoroacetic acid (TFA) remover based on electrodialysis with bipolar membrane for online coupling of liquid chromatography (LC) and electrospray ionization mass spectrometry (ESI-MS) using TFA containing mobile phase. With the TFA remover as an interface, the TFA anion in the mobile phase was removed based on electrodialysis mechanism, and meanwhile, the anion exchange membrane was self-regenerated by the hydroxide ions produced by the bipolar membrane. So the remover could continuously work without any additional regeneration process. The established LC-TFA remover-MS system has been successfully applied for the qualitative and quantitative analysis of small molecules as well as proteins.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305231700016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy; SCI(E); EI; PubMed; 0; ARTICLE; 7; 1289-1292; 23 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/149888] ![]() |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Zhou, Zhigui,Zhang, Jialing,Xing, Jiawei,et al. Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins[J]. journal of the american society for mass spectrometry,2012. |
APA | Zhou, Zhigui,Zhang, Jialing,Xing, Jiawei,Bai, Yu,Liao, Yiping,&Liu, Huwei.(2012).Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins.journal of the american society for mass spectrometry. |
MLA | Zhou, Zhigui,et al."Membrane-Based Continuous Remover of Trifluoroacetic Acid in Mobile Phase for LC-ESI-MS Analysis of Small Molecules and Proteins".journal of the american society for mass spectrometry (2012). |
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