Simultaneous and sensitive capillary electrophoretic enantioseparation   of three beta-blockers with the combination of achiral ionic liquid and   dual CD derivatives

doi:10.1016/j.talanta.2011.12.005

CORC > 北京大学 > 化学与分子工程学院

	Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives
	Jin, Yue ; Chen, Cheng ; Meng, Lingchen ; Chen, Jitao ; Li, Meixian ; Zhu, Zhiwei
刊名	talanta
	2012
关键词	Achiral ionic liquid beta-Cyclodextrin Enantioseparation beta-Blocker ELECTROKINETIC CHROMATOGRAPHY CYCLODEXTRINS SEPARATIONS
DOI	10.1016/j.talanta.2011.12.005
英文摘要	Successful simultaneous enantioseparation and sensitive determination of three beta-blockers (PIN, OX and PRO), have been achieved by capillary electrophoresis using an achiral ionic liquid, [GTMA]Cl, as a modifier to cooperate with dual CDs containing DM-beta-CD and TM-beta-CD. The influence of aIL was investigated in details, including various aILs, the concentration of aIL and molar ratio of aIL to CD. The ratio of DM-beta-CD to TM-beta-CD in dual CDs was also discussed. DM-beta-CD and TM-beta-CD favor the enantioseparations of PIN/OX and PRO, respectively. Meanwhile, the presence of [GTMA]Cl was found to play a key role in enantioseparations, and it widened the scope of application of DM-beta-CD and TM-beta-CD. Furthermore, FESI as an effective on-line sample enrichment technique was developed to improve the detection sensitivity. Under the optimum conditions, the detection limits of the three pairs of enantiomers range from 0.10 to 0.65 nM, which are much lower than those in the conventional methods. Eventually, the proposed method was successfully applied to the analysis of spiked urine sample with good recoveries. (C) 2011 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301278000022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Analytical; SCI(E); EI; PubMed; 14; ARTICLE; 149-154; 89
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149867]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Jin, Yue,Chen, Cheng,Meng, Lingchen,et al. Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives[J]. talanta,2012.
APA	Jin, Yue,Chen, Cheng,Meng, Lingchen,Chen, Jitao,Li, Meixian,&Zhu, Zhiwei.(2012).Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives.talanta.
MLA	Jin, Yue,et al."Simultaneous and sensitive capillary electrophoretic enantioseparation of three beta-blockers with the combination of achiral ionic liquid and dual CD derivatives".talanta (2012).