Robustness in Protein Folding Revealed by Thermodynamics Calculations

doi:10.1021/jp307684h

CORC > 北京大学 > 化学与分子工程学院

	Robustness in Protein Folding Revealed by Thermodynamics Calculations
	Shao, Qiang ; Zhu, Weiliang ; Gao, Yi Qin
刊名	journal of physical chemistry b
	2012
关键词	MOLECULAR-DYNAMICS SIMULATIONS INTER-RESIDUE INTERACTIONS TRP-CAGE B-DOMAIN STRUCTURE PREDICTION BETA-HAIRPIN SIDE-CHAIN SECONDARY STRUCTURE BUNDLE PROTEINS G29A MUTANT
DOI	10.1021/jp307684h
英文摘要	Long-range intraprotein interactions play important roles in protein folding. In the present study, we use two variants of the B domain of protein A (BdpA F14W/G30A and BdpA_ds) and two variants of the Trp cage (TC5b_P1 and TC5b_P2) as models to investigate how long-range hydrophobic interactions affect protein tertiary and secondary structures. The mutation of the selected residues (BdpA F14W/G30A) or the change in the sequence order of Helix1 and Helix2 (BdpA_ds) changes detailed hydrophobic interactions. However, this change does not alter the global three-helix-bundle structure of BdpA and the overall shape of the folding free-energy landscape. It does affect the formation and stability of individual secondary structures. Similarly, the addition of an extra segment to the C-terminus of Trp-cage increases the number of long-range hydrophobic interactions without making any significant change of the native structure of Trp-cage. These results show the robustness of the overall protein folding where rather large sequence changes exert significant influences on secondary but not tertiary structures.; Chemistry, Physical; SCI(E); EI; PubMed; 5; ARTICLE; 47; 13848-13856; 116
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149831]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Shao, Qiang,Zhu, Weiliang,Gao, Yi Qin. Robustness in Protein Folding Revealed by Thermodynamics Calculations[J]. journal of physical chemistry b,2012.
APA	Shao, Qiang,Zhu, Weiliang,&Gao, Yi Qin.(2012).Robustness in Protein Folding Revealed by Thermodynamics Calculations.journal of physical chemistry b.
MLA	Shao, Qiang,et al."Robustness in Protein Folding Revealed by Thermodynamics Calculations".journal of physical chemistry b (2012).