Computational Design of Helical Peptides Targeting TNF alpha

doi:10.1002/anie.201305963

CORC > 北京大学 > 化学与分子工程学院

	Computational Design of Helical Peptides Targeting TNF alpha
	Zhang, Changsheng ; Shen, Qi ; Tang, Bo ; Lai, Luhua
刊名	angewandte chemie international edition
	2013
关键词	computational design helical peptides protein peptide drug protein-protein interactions TNF NECROSIS-FACTOR-ALPHA CRYSTAL-STRUCTURE RECEPTOR-BINDING SEQUENCE PROTEINS AFFINITY
DOI	10.1002/anie.201305963
英文摘要	Find and bind: A computational strategy for designing single-helical peptides that can bind to a target protein was developed. After identification of potential helix-binding positions, sequences and binding conformations were derived theoretically, and explored by experimental screening. This method was successfully applied in designing peptide inhibitors for a therapeutic target, tumor necrosis factor-α (TNFα).Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000328812600022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Chemistry, Multidisciplinary; SCI(E); EI; PubMed; 6; ARTICLE; 42; 11059-11062; 52
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149744]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Zhang, Changsheng,Shen, Qi,Tang, Bo,et al. Computational Design of Helical Peptides Targeting TNF alpha[J]. angewandte chemie international edition,2013.
APA	Zhang, Changsheng,Shen, Qi,Tang, Bo,&Lai, Luhua.(2013).Computational Design of Helical Peptides Targeting TNF alpha.angewandte chemie international edition.
MLA	Zhang, Changsheng,et al."Computational Design of Helical Peptides Targeting TNF alpha".angewandte chemie international edition (2013).