Complete dissociation and reassembly behavior as studied by using   poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A

doi:10.1039/c4sm02656j

CORC > 北京大学 > 化学与分子工程学院

	Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A
	Wen, Hao ; Pan, Wei ; Zhou, Jihan ; Li, Zhibo ; Liang, Dehai
刊名	软性材料
	2015
关键词	BLOCK-COPOLYMER MICELLES DRUG-DELIVERY POLYMERIC MICELLES DIBLOCK COPOLYMER GENE DELIVERY POLYELECTROLYTE TRIFLUOROETHANOL COACERVATION STABILITY ACIDS)
DOI	10.1039/c4sm02656j
英文摘要	Kanamycin A, an amino modified sugar, can interact with poly(ethylene glycol)-block-poly(glutamate sodium) (PEG(114)-PGlu(64)) via electrostatic interactions (with PGlu) and hydrogen bonding (with PEG). The interplay of these two forces determines the assembly process and the resulting structure. In deionized water, kanamycin A and PEG(114)-PGlu(64) form a spherical structure at [+]/[-] = 3.5. This structure dissociates instantly and completely in the presence of 30 mM NaCl. However, a new structure is reassembled in about 2 hours. A similar phenomenon is observed when the buffer pH is increased from 7.8 to 8.3. We attribute the distinct dissociation/reassembly process to the reestablishment of the balance between electrostatic interactions and hydrogen bonding. The dissociation/reassembly process in response to environmental changes offers a novel approach to release the loaded cargo in a controlled manner.; Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science; SCI(E); EI; PubMed; 0; ARTICLE; zbli@iccas.ac.cn; dliang@pku.edu.cn; 10; 1930-1936; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149645]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wen, Hao,Pan, Wei,Zhou, Jihan,et al. Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A[J]. 软性材料,2015.
APA	Wen, Hao,Pan, Wei,Zhou, Jihan,Li, Zhibo,&Liang, Dehai.(2015).Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A.软性材料.
MLA	Wen, Hao,et al."Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A".软性材料 (2015).