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毛细管区带电泳法分析头孢菌素类药物的纯度; Purity analysis of cephalosporins with capillary zone electrophoresis
龙虹 ; 丁强 ; 王天松 ; 黄爱今 ; 孙亦梁
1999
关键词毛细管区带电泳 纯度测定 内部归一化法 头孢菌素
英文摘要提出了以pH 9.20的20 m m ol/L硼酸缓冲溶液、pH 6.86的20 m m ol/L磷酸缓冲溶液和pH 2.05 的50m m ol/L磷酸缓冲溶液作为背景电解质分析9种头孢菌素类抗生素药物纯度的毛细管区带电泳方法。用内部归一化法定量,方法简单快速。讨论了方法的优点和局限性。; A capillary zone electrophoresis method is proposed for the purity determination of nine cephalosporin drugs. A background electrolyte comprising of either 20 mmol/L pH 9.20 borate buffer or 20 mmol/L pH 6.86 phosphate buffer was used for most drugs studied except for cefaloridine which formed neutral molecules at these pH values. For it 50 mmol/L pH 2.05 phosphate buffer was used instead. Internal normalization method was employed for quantitation. The method is simple, rapid and versatile. Analysis was completed within 8 min. The merits and limitations of the method were also discussed.; PubMed; 中文核心期刊要目总览(PKU); 中国科学引文数据库(CSCD); 0; 06; 570-572; 17
语种中文
出处PubMed ; 知网
出版者色谱
内容类型其他
源URL[http://hdl.handle.net/20.500.11897/77961]  
专题化学与分子工程学院
推荐引用方式
GB/T 7714
龙虹,丁强,王天松,等. 毛细管区带电泳法分析头孢菌素类药物的纯度, Purity analysis of cephalosporins with capillary zone electrophoresis. 1999-01-01.
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