QQ客服 官方微博 反馈留言

	Practical reconstruction method for bioluminescence tomography
	Cong, WX ; Wang, G ; Kumar, D ; Liu, Y ; Jiang, M ; Wang, LV ; Hoffman, EA ; McLennan, G ; McCray, PB ; Zabner, J ; Cong, A
	2005
关键词	OPTICAL-PROPERTIES SCATTERING MEDIA GENE-EXPRESSION REPORTER GENE LIVING MICE LIGHT PROPAGATION TISSUE MODEL
英文摘要	Bioluminescence tomography (BLT) is used to localize and quantify bioluminescent sources in a small living animal. By advancing bioluminescent imaging to a tomographic framework, it helps to diagnose diseases, monitor therapies and facilitate drug development. In this paper, we establish a direct linear relationship between measured surface photon density and an unknown bioluminescence source distribution by using a finite- element method based on the diffusion approximation to the photon propagation in biological tissue. We develop a novel reconstruction algorithm to recover the source distribution. This algorithm incorporates a priori knowledge to define the permissible source region in order to enhance numerical stability and efficiency. Simulations with a numerical mouse chest phantom demonstrate the feasibility of the proposed BLT algorithm and reveal its performance in terms of source location, density, and robustness against noise. Lastly, BLT experiments are performed to identify the location and power of two light sources in a physical mouse chest phantom. (c) 2005 Optical Society of America; Optics; SCI(E); EI; 0; ARTICLE; 18; 6756-6771; 13
语种	英语
出处	SCI ; EI
出版者	光学快报
内容类型	其他
源URL	[http://hdl.handle.net/20.500.11897/399129]
专题	数学科学学院
推荐引用方式 GB/T 7714	Cong, WX,Wang, G,Kumar, D,et al. Practical reconstruction method for bioluminescence tomography. 2005-01-01.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。