Early life stress predicts cortisol response to psychosocial stress in healthy young adults | |
Zhang, Huihui1,2; Yao, Zhuxi1,3; Lin, Li1,2; Sun, Xiaofang1,4; Shi, Xia1; Zhang, Liang1,2 | |
刊名 | PSYCH JOURNAL |
2019-09-01 | |
卷号 | 8期号:3页码:353-362 |
关键词 | cortisol early life stress hypothalamic-pituitary-adrenal axis psychosocial stress |
ISSN号 | 2046-0252 |
DOI | 10.1002/pchj.278 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Repeated exposure to stress during early life has a lifetime impact on physical and psychological functions. Our study investigated the long-term effects of early life stress (ELS; measured retrospectively) on the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system functions under psychosocial stress among healthy adults. Fifty healthy volunteers (33 male, 17 female, mean age 22.6 +/- 1.8 years) underwent a standardized psychosocial stress protocol (the Trier Social Stress Test), with the collection of salivary cortisol, heart rates, and positive and negative affect. The results showed increases in cortisol, heart rate, and negative affect after the stress inducement. More importantly, a significant negative correlation was found between the severity of ELS and the increase of cortisol to the stress. The severity of stress in one's early life predicted his/her cortisol reactivity to the stress in adulthood. Neither the heart rate reactivity nor the affective reactivity shows significant association with ELS. The blunted cortisol reactivity reflects the alteration of the HPA axis, which may confer the risk for certain stress-related disorders. |
资助项目 | National Key Research and Development Plan[2018YFC0831101] ; National Science Foundation of China[U1736220] |
WOS关键词 | ADVERSE CHILDHOOD EXPERIENCES ; AXIS REACTIVITY ; SOCIAL STRESS ; TRAUMA ; WOMEN ; PATHOPHYSIOLOGY ; ASSOCIATIONS ; POPULATION ; VALIDATION ; DISORDERS |
WOS研究方向 | Psychology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000483561000008 |
资助机构 | National Key Research and Development Plan ; National Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/29845] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Zhang, Liang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China 4.Tsinghua Univ, Dept Ind Engn, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Huihui,Yao, Zhuxi,Lin, Li,et al. Early life stress predicts cortisol response to psychosocial stress in healthy young adults[J]. PSYCH JOURNAL,2019,8(3):353-362. |
APA | Zhang, Huihui,Yao, Zhuxi,Lin, Li,Sun, Xiaofang,Shi, Xia,&Zhang, Liang.(2019).Early life stress predicts cortisol response to psychosocial stress in healthy young adults.PSYCH JOURNAL,8(3),353-362. |
MLA | Zhang, Huihui,et al."Early life stress predicts cortisol response to psychosocial stress in healthy young adults".PSYCH JOURNAL 8.3(2019):353-362. |
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