Lifespan normative data on rates of brain volume changes | |
Battaglini, Marco1; Gentile, Giordano1; Luchetti, Ludovico1; Giorgio, Antonio1; Vrenken, Hugo2; Barkhof, Frederik2,3,4,5; Cover, Keith S.2,6; Bakshi, Rohit7; Chu, Renxin7; Sormani, Maria Pia8 | |
刊名 | NEUROBIOLOGY OF AGING
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2019-09-01 | |
卷号 | 81页码:30-37 |
关键词 | Normative data Atrophy Aging MRI Brain volume |
ISSN号 | 0197-4580 |
DOI | 10.1016/j.neurobiolaging.2019.05.010 |
文献子类 | article |
英文摘要 | We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting. (C) 2019 Published by Elsevier Inc. |
资助项目 | National Institute for Health Research University College London Hospitals Biomedical Research Centre, UK |
WOS关键词 | CLINICAL-RELEVANCE ; ATROPHY ; MRI ; DIAGNOSIS ; ROBUST ; GRAY |
WOS研究方向 | Geriatrics & Gerontology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000484435300004 |
资助机构 | National Institute for Health Research University College London Hospitals Biomedical Research Centre, UK |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/29814] ![]() |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | De Stefano, Nicola |
作者单位 | 1.Univ Siena, Dept Med Surg & Neurosci, Viale Bracci 2, I-53100 Siena, Italy 2.MS Ctr Amsterdam, Dept Radiol & Nucl Med, Amsterdam, Netherlands 3.UCL London, Inst Neurol, London, England 4.UCL London, Inst Healthcare Engn, London, England 5.UCLH, BRC, NIHR, London, England 6.Vrije Univ Amsterdam, Dept Phys & Med Technol, Med Ctr, Amsterdam, Netherlands 7.Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Lab Neuroimaging Res, Boston, MA 02115 USA 8.Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy 9.Med Univ Graz, Dept Neurol, Graz, Austria 10.Med Univ Graz, Dept Radiol, Div Neuroradiol Vasc & Intervent Radiol, Graz, Austria |
推荐引用方式 GB/T 7714 | Battaglini, Marco,Gentile, Giordano,Luchetti, Ludovico,et al. Lifespan normative data on rates of brain volume changes[J]. NEUROBIOLOGY OF AGING,2019,81:30-37. |
APA | Battaglini, Marco.,Gentile, Giordano.,Luchetti, Ludovico.,Giorgio, Antonio.,Vrenken, Hugo.,...&De Stefano, Nicola.(2019).Lifespan normative data on rates of brain volume changes.NEUROBIOLOGY OF AGING,81,30-37. |
MLA | Battaglini, Marco,et al."Lifespan normative data on rates of brain volume changes".NEUROBIOLOGY OF AGING 81(2019):30-37. |
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