Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

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	Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects
	Nune, KC; Li, SJ; Misra, RDK; Misra, RDK (reprint author), Univ Texas El Paso, Mat & Biomed Engn Dept, Biomaterials Sci & Engn Lab Met, El Paso, TX 79968 USA.
刊名	SCIENCE CHINA-MATERIALS
	2018-04-01
卷号	61 期号:4 页码:455-474
关键词	Bmp-induced Osteogenesis Free-form Fabrication In-vivo Performance Porous Tantalum Bone Ingrowth Osteoblast Functions Dental Implants Stem-cells Pore-size Surface Modification
ISSN号	2095-8226
英文摘要	We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.; We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.
学科主题	Materials Science, Multidisciplinary
语种	英语
资助机构	Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso; Key Research Program of Frontier Science, CAS [QYZDJ-SSW-JSC031-02]
公开日期	2018-06-05
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/79380]
专题	金属研究所_中国科学院金属研究所
通讯作者	Misra, RDK (reprint author), Univ Texas El Paso, Mat & Biomed Engn Dept, Biomaterials Sci & Engn Lab Met, El Paso, TX 79968 USA.
推荐引用方式 GB/T 7714	Nune, KC,Li, SJ,Misra, RDK,et al. Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects[J]. SCIENCE CHINA-MATERIALS,2018,61(4):455-474.
APA	Nune, KC,Li, SJ,Misra, RDK,&Misra, RDK .(2018).Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects.SCIENCE CHINA-MATERIALS,61(4),455-474.
MLA	Nune, KC,et al."Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects".SCIENCE CHINA-MATERIALS 61.4(2018):455-474.