The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms

doi:10.1007/s10534-016-9942-4

	The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms
	Hu, Y; Chai, ZF; Chen, J; Lan AP(兰爱平); Chen J(陈俊); Chai ZF(柴之芳); Hu Y(胡毅); Lan, AP
刊名	BIOMETALS
	2016
卷号	29 期号:4 页码:665-678
关键词	Parkinson's disease Reactive oxygen species Iron Copper Cobalt
ISSN号	0966-0844
DOI	10.1007/s10534-016-9942-4
文献子类	Article
英文摘要	Parkinson's disease (PD) is the second most common neurodegenerative disease with gradual loss of dopaminergic neurons. Despite extensive research in the past decades, the etiology of PD remains elusive. Nevertheless, multiple lines of evidence suggest that oxidative stress is one of the common causes in the pathogenesis of PD. It has also been suggested that heavy metal-associated oxidative stress may be implicated in the etiology and pathogenesis of PD. Here we review the roles of redox metals, including iron, copper and cobalt, in PD. Iron is a highly reactive element and deregulation of iron homeostasis is accompanied by concomitant oxidation processes in PD. Copper is a key metal in cell division process, and it has been shown to have an important role in neurodegenerative diseases such as PD. Cobalt induces the generation of reactive oxygen species (ROS) and DNA damage in brain tissues.
电子版国际标准刊号	1572-8773
语种	英语
WOS记录号	WOS:000381144200008
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/287068]
专题	高能物理研究所_院士
推荐引用方式 GB/T 7714	Hu, Y,Chai, ZF,Chen, J,et al. The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms[J]. BIOMETALS,2016,29(4):665-678.
APA	Hu, Y.,Chai, ZF.,Chen, J.,兰爱平.,陈俊.,...&Lan, AP.(2016).The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms.BIOMETALS,29(4),665-678.
MLA	Hu, Y,et al."The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms".BIOMETALS 29.4(2016):665-678.