pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells

doi:10.3390/nano8110952

	pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells
	Zhou MX(周梦雪); Xie J(谢进); Qi RX(齐荣翔); Lu HR(卢会茹); Chen J(陈俊); Hu, Y.; Chen, J.; Hu Y(胡毅); Leporatti, S.; Lu, H.
刊名	NANOMATERIALS
	2018
卷号	8 期号:11 页码:952
关键词	nanoparticles pH responsive poly(beta-amino ester)s doxorubicin multidrug resistance
ISSN号	2079-4991
DOI	10.3390/nano8110952
文献子类	Article
英文摘要	Multidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(beta-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape in MCF-7/ADR cells. The cytotoxicity assays showed relatively higher cell inhibition of DOX-loaded PHP micelles than that of free DOX against MCF-7/ADR cells. Further mechanistic studies showed that PHP micelles were able to inhibit P-glycoprotein (P-gp) activity by lowering mitochondrial membrane potentials and ATP levels. These results suggested that the enhanced antitumor effect might be attributed to PHP-mediated lysosomal escape and drug efflux inhibition. Therefore, PHP would be a promising pH-responsive nanocarrier for enhanced intracellular drug delivery and overcoming MDR in cancer cells.
WOS关键词	VITAMIN-E TPGS ; MULTIDRUG-RESISTANCE ; DOXORUBICIN DELIVERY ; ANTICANCER DRUG ; IN-VITRO ; NANOPARTICLES ; COPOLYMER ; MICELLES ; REVERSAL ; METASTASIS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000451316100087
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286982]
专题	高能物理研究所_多学科研究中心高能物理研究所_实验物理中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhou MX,Xie J,Qi RX,et al. pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells[J]. NANOMATERIALS,2018,8(11):952.
APA	周梦雪.,谢进.,齐荣翔.,卢会茹.,陈俊.,...&Zhou, M..(2018).pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells.NANOMATERIALS,8(11),952.
MLA	周梦雪,et al."pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells".NANOMATERIALS 8.11(2018):952.