Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment

doi:10.1002/adhm.201800525

	Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment
	Wang LM(王黎明); Chen, C.; Wang, L.; Saleem, J.
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:20 页码:1800525
关键词	angiogenesis cancer stem cells carbon nanomaterials immune stimulations tumor microenvironments
ISSN号	2192-2640
DOI	10.1002/adhm.201800525
文献子类	Review
英文摘要	Cancer remains one of the major health problems all over the world and conventional therapeutic approaches have failed to attain an effective cure. Tumor microenvironments (TME) present a unique challenge in tumor therapy due to their complex structures and multiple components, which also serve as the soil for tumor growth, development, invasion, and migration. The complex TME includes immune cells, fibrous collagen structures, and tortuous blood vessels, in which conventional therapeutic approaches are rendered useless. State-of-the-art nanotechnologies have potential to cope with the threats of malignant tumors. With unique physiochemical properties, carbon nanomaterials (CNMs), including graphene, fullerenes, carbon nanotubes, and carbon quantum dots, offer opportunities to resolve the hurdles, by targeting not only cancer cells but also the TME. This review summarizes the progress about CNM-based cancer therapy strategies, which mainly focuses on both the treatment for cancer cells and TME-targeted modulation. In the last, the challenges for TME-based therapy via CNMs are discussed, which will be important in guiding current basic research to clinical translation in the future.
电子版国际标准刊号	2192-2659
WOS关键词	MESENCHYMAL STEM-CELLS ; REDUCED GRAPHENE OXIDE ; ANTICANCER DRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; PHOTODYNAMIC THERAPY ; BREAST-CANCER ; FULLERENE DERIVATIVES ; SIGNALING PATHWAYS ; CONTROLLED-RELEASE
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000448900700017
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286950]
专题	高能物理研究所_多学科研究中心
通讯作者	Wang LM(王黎明)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang LM,Chen, C.,Wang, L.,et al. Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(20):1800525.
APA	王黎明,Chen, C.,Wang, L.,&Saleem, J..(2018).Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment.ADVANCED HEALTHCARE MATERIALS,7(20),1800525.
MLA	王黎明,et al."Carbon-Based Nanomaterials for Cancer Therapy via Targeting Tumor Microenvironment".ADVANCED HEALTHCARE MATERIALS 7.20(2018):1800525.