Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles

doi:10.1002/smll.201802549

	Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles
	Qin YX(秦艳霞); Bai X(白雪); Chang YN(常亚男); Gu, Weihong; Chen, Kui; Zhao, Xiaoyi; Geng, Huan; Li, Juan; Qin, Yanxia; Bai, Xue
刊名	SMALL
	2018
卷号	14 期号:48 页码:1802549
关键词	actin fullerenol osteoporosis ruffled borders synchrotron radiation small angle X-ray scattering (SAXS)
ISSN号	1613-6810
DOI	10.1002/smll.201802549
文献子类	Article
英文摘要	Osteoporosis, a common and serious bone disorder affecting aged people and postmenopausal women, is characterized by osteoclast overactivity. One therapeutic strategy is suppressing the bone resorption function of hyperactive osteoclasts, but there is no effective drug in clinical practice so far. Herein, it is demonstrated that fullerenols suppress the bone resorption of osteoclasts by inhibiting ruffled borders (RBs) formation. The RBs formation, which is supported by well-aligned actin bundles (B-actins), is a critical event for osteoclast bone resorption. To facilitate this function, osteoclast RBs dynamics is regulated by variable microenvironments to bundle F-actins, protrude cell membrane, and so on. B-actin perturbation by fullerenols is determined here, offering an opportunity to regulate osteoclast function by destroying RBs. In vivo, the therapeutic effect of fullerenols on overactive osteoclasts is confirmed in a mouse model of lipopolysaccharide-induced bone erosion. Collectively, the findings suggest that fullerenols adhere to F-actin surfaces and inhibit RBs formation in osteoclasts, mainly through hampering Ca2+ from bundling F-actins, and this is likely due to the stereo-hindrance effect caused by adherent fullerenols.
电子版国际标准刊号	1613-6829
WOS关键词	F-ACTIN ; CELLULAR UPTAKE ; IN-VITRO ; NANOPARTICLES ; CALCIUM ; ORGANIZATION ; POLYAMINES ; MECHANISM ; DIFFERENTIATION ; CYTOTOXICITY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000451566800009
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286897]
专题	高能物理研究所_多学科研究中心
通讯作者	Xing GM(邢更妹)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Qin YX,Bai X,Chang YN,et al. Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles[J]. SMALL,2018,14(48):1802549.
APA	秦艳霞.,白雪.,常亚男.,Gu, Weihong.,Chen, Kui.,...&李娟.(2018).Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles.SMALL,14(48),1802549.
MLA	秦艳霞,et al."Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles".SMALL 14.48(2018):1802549.