Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues

doi:10.1002/adhm.201800421

	Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues
	Wang, C.; Zhao YL(赵宇亮); Gu ZJ(谷战军); Zhao F(赵峰); Wang CY(汪诚艳); Xie JN(谢佳妮); Zhao, F.; Gu, Z.; Zhao, Y.; Xie, J.
刊名	ADVANCED HEALTHCARE MATERIALS
	2018
卷号	7 期号:20 页码:1800421
关键词	multifunctional nanomaterials nanocarriers nanoradioprotectors radioprotection radioprotective mechanisms
ISSN号	2192-2640
DOI	10.1002/adhm.201800421
文献子类	Review
英文摘要	Radiotherapy has been extensively used in clinic for malignant tumors treatment. However, a severe challenge of it is that the ionizing radiation needed to kill tumors inevitably causes damage to surrounding normal tissues. Although some of the molecular radioprotective drugs, such as amifostine, have been used as clinical adjuvants to radio-protect healthy tissues, their shortcomings such as short systemic circulation time and fast biological clearing from the body largely hinder the sustained bioactivity. Recently, with the rapid development of nanotechnology in the biological field, the multifunctional nanomaterials not only establish powerful drug delivery systems to improve the molecular radioprotective drugs' biological availability, but also open a new route to develop neozoic radioprotective agents because some nanoparticles possess intrinsic radioprotective abilities. Therefore, considering these overwhelming superiorities, this review systematically summarizes the advances in healthy tissue radioprotection applications of multifunctional nanomaterials. Furthermore, this review also points out a perspective of nanomaterial designs for radioprotection applications and discusses the challenges and future outlooks of the nanomaterial-mediated radioprotection.
电子版国际标准刊号	2192-2659
WOS关键词	CERIUM OXIDE NANOPARTICLES ; BAMBOO CHARCOAL NANOPARTICLES ; RADIATION-INDUCED DAMAGES ; WALLED CARBON NANOTUBES ; BLOOD MONONUCLEAR-CELLS ; SILVER NANOPARTICLE ; IN-VIVO ; GAMMA-RADIATION ; DNA-DAMAGE ; FULLERENOL C-60(OH)(24)
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
WOS记录号	WOS:000448900700012
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286896]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, C.,Zhao YL,Gu ZJ,et al. Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(20):1800421.
APA	Wang, C..,赵宇亮.,谷战军.,赵峰.,汪诚艳.,...&Xie, J..(2018).Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues.ADVANCED HEALTHCARE MATERIALS,7(20),1800421.
MLA	Wang, C.,et al."Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues".ADVANCED HEALTHCARE MATERIALS 7.20(2018):1800421.