Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection

doi:10.1002/chem.201803040

	Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection
	Gu, Zhanjun; Ma DQ(马东清); Yu J(余杰); Yin WY(尹文艳); Zhang X(张潇); Mei LQ(梅林强); Zu Y(祖艳); Gu ZJ(谷战军); Ma, Dongqing; Yu, Jie
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2018
卷号	24 期号:59 页码:15868-15878
关键词	cholesterol detection nanosized MoS2 peroxidase-like activity steady-state kinetics surface modification
ISSN号	0947-6539
DOI	10.1002/chem.201803040
文献子类	Article
英文摘要	Abnormal H2O2 and cholesterol levels are closely related to many diseases. This work reports a facile process for the synthesis of oxidized glutathione (GSSG)-modified MoS2 nanosheets (MoS2-GSSG NSs). The biocompatible MoS2-GSSG NSs have good dispersibility and high affinity to the substrate 3,3 ',5,5 '-tetramethylbenzidine (TMB), which is beneficial for improving peroxidase-like catalytic activity of MoS2. The high peroxidase-like activity of MoS2-GSSG NSs was applied as a robust nanoplatform for low-cost, rapid, and highly effective colorimetric detection of H2O2 and total/free cholesterol. Moreover, the peroxidase-like catalytic mechanism was studied by the steady-state kinetics method. The catalytic activity was remarkably high at a wide range of pH (2.4-7.0) and temperature values (25-70 degrees C). The cholesterol was catalyzed by cholesterol oxidase (ChOx) in the presence of O-2 to generate H2O2, which oxidized TMB to generate a blue-colored product (oxTMB) under the catalysis of MoS2-GSSG NSs. The detection limit (DL) of total cholesterol and H2O2 was as low as 5.36 and 0.51 mu m, respectively. The linear ranges for detecting cholesterol and H2O2 were from 5.36 to 800 mu m and from 0.51 to 50 mu m, respectively. This method was also successfully applied to the detection of cholesterol in serum. The detection concentration of total cholesterol was consistent with that of the value detected by the blood biochemical method used in the clinic.
电子版国际标准刊号	1521-3765
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; SENSITIVE COLORIMETRIC DETECTION ; GUIDED PHOTOTHERMAL THERAPY ; GRAPHENE QUANTUM DOTS ; SINGLE-LAYER MOS2 ; GLUCOSE DETECTION ; DRUG-DELIVERY ; ELECTROCHEMICAL DETECTION ; ANTIBACTERIAL ACTIVITY ; GOLD NANOPARTICLES
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000448057800024
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286860]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gu, Zhanjun,Ma DQ,Yu J,et al. Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection[J]. CHEMISTRY-A EUROPEAN JOURNAL,2018,24(59):15868-15878.
APA	Gu, Zhanjun.,马东清.,余杰.,尹文艳.,张潇.,...&An, Lijuan.(2018).Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection.CHEMISTRY-A EUROPEAN JOURNAL,24(59),15868-15878.
MLA	Gu, Zhanjun,et al."Synthesis of Surface-Modification-Oriented Nanosized Molybdenum Disulfide with High Peroxidase-Like Catalytic Activity for H2O2 and Cholesterol Detection".CHEMISTRY-A EUROPEAN JOURNAL 24.59(2018):15868-15878.