Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent

doi:10.1016/j.colsurfb.2018.07.026

	Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent
	Sun, Baoyun; Li C(李成); Huang H(黄换); Cui RL(崔荣丽); Li J(李娟); Guo XH(郭喜红); Yao HL(要换丽); Liu B(刘兵); Xu BG(徐秉刚); Li Y(李颖)
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2018
卷号	171 页码:159-166
关键词	Gadofullerene nanoprobes Fluorescent activatable MRI Dual Imaging agents
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2018.07.026
文献子类	Article
英文摘要	Dual mode imaging technology is widely developed to achieve the early-stage precision cancer diagnosis. Here we designed a dual-modal magnetic resonance/near infrared fluorescence optical imaging contrast agent (GdF-SS-NIR783) with the fluorescence activatable and safer gadofullerene. The nanoprobes were fabricated by conjugating the gadofullerene derivatives with a NIR fluorescence imaging agent (NIR783) via the disulfide bond. The obtained nanoprobes showed no fluorescence (OFF), but the fluorescence turned on when incubated within reduction environment such as GSH solution. The clear fluorescence signal in tumor site was observed obviously after their intraturnor injection. The nanoprobes also revealed efficient MRI contrast enhancement both in Vitra and in vivo. And they showed good biocompatibility and did not demonstrate any tissue toxicity in vivo. This work gave the new possibility in designing more efficient and safer nanoprobes for future medical diagnoses,
电子版国际标准刊号	1873-4367
WOS关键词	MAGNETIC-RESONANCE ; NANOPARTICLES ; NANOCOMPOSITE ; GD-AT-C-2V(9)-C-82 ; METALLOFULLERENE ; METAL
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
WOS记录号	WOS:000447575400020
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286605]
专题	高能物理研究所_多学科研究中心
通讯作者	Sun BY(孙宝云)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Sun, Baoyun,Li C,Huang H,et al. Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,171:159-166.
APA	Sun, Baoyun.,李成.,黄换.,崔荣丽.,李娟.,...&Xing, Gengmei.(2018).Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent.COLLOIDS AND SURFACES B-BIOINTERFACES,171,159-166.
MLA	Sun, Baoyun,et al."Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent".COLLOIDS AND SURFACES B-BIOINTERFACES 171(2018):159-166.