Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia

doi:10.3389/fpsyt.2018.00391

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	Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia
	Dan BC(单保慈); Long, YC; Ouyang, X; Liu, ZN; Chen, XD; Hu, XR; Lee, E; Chen, EYH; Pu, WD; Shan, BC
刊名	FRONTIERS IN PSYCHIATRY
	2018
卷号	9 页码:391
关键词	first-episode schizophrenia suicide suicidal ideation diffusion tensor imaging (DTI) white matter cognitive function
ISSN号	1664-0640
DOI	10.3389/fpsyt.2018.00391
文献子类	Article
英文摘要	Objective: The study was aimed to investigate the possible associations among suicidal ideation, brain white matter (WM) integrity and cognitive deficit in first-episode schizophrenia (FES) using diffusion tensor imaging. Methods: The sample contained 18 FES patients with suicidal ideation (SI+), 45 FES patients without suicidal ideation (SI-) and 44 healthy controls. The Calgary Depression Scale for Schizophrenia was used to measure the suicidal ideation and depression symptoms. The whole brain WM integrity and three domains of cognitive function: working memory, verbal comprehension as well as processing speed were compared between the three groups. Results: Compared with SI-, SI+ showed preserved WM integrity as indicated by significantly higher factional anisotropy (FA) or lower mean diffusivity (MD) in multiple WM tracts, and higher FA coupled with lower MD in bilateral posterior corona radiata. Compared with SI-, SI+ were more depressed and had less cognitive deficit in working memory and verbal comprehension. The fiber tracts in bilateral posterior corona radiata connect to the precuneus as shown by probabilistic tractography, and their WM integrity disruptions were found to be positively associated with the cognitive deficits in the FES patients. Discussion: Preserved WM integrity may be a risk factor for suicidal ideation in FES patients. One possible explanation is that it contributes to preserved cognitive function, especially in working memory and verbal comprehension, which may be associated with greater insight and could lead to increased depression and suicidal ideation. The posterior corona radiata and the precuneus may be linked to the related biological processes.
WOS关键词	1ST-EPISODE PSYCHOSIS ; NEUROCOGNITIVE FUNCTION ; FUNCTIONAL CONNECTIVITY ; INSIGHT DIMENSIONS ; DEFAULT MODE ; WHOLE-BRAIN ; DIFFUSION ; BEHAVIOR ; MICROSTRUCTURE ; ABNORMALITIES
WOS研究方向	Psychiatry
语种	英语
WOS记录号	WOS:000442884700001
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/286245]
专题	高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Dan BC,Long, YC,Ouyang, X,et al. Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2018,9:391.
APA	单保慈.,Long, YC.,Ouyang, X.,Liu, ZN.,Chen, XD.,...&Rohrbaugh, RM.(2018).Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia.FRONTIERS IN PSYCHIATRY,9,391.
MLA	单保慈,et al."Associations Among Suicidal Ideation, White Matter Integrity and Cognitive Deficit in First-Episode Schizophrenia".FRONTIERS IN PSYCHIATRY 9(2018):391.