Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake

doi:10.1002/jlcr.3611

CORC > 高能物理研究所 > 中国科学院高能物理研究所 > 核技术应用研究中心

	Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake
	Zhao, QY; Yang, WJ; Zhang, YH; Xue, JQ; Liu, Y; Wang JJ(汪建军); Yang WJ(杨文江); Xue JQ(薛金泉); Zhang YH(张延华); 刘宇(多)
刊名	JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
	2018
卷号	61 期号:4 页码:395-401
关键词	Tc-99m DTPA-colchicine dimer label tumor uptake
ISSN号	0362-4803
DOI	10.1002/jlcr.3611
文献子类	Article
英文摘要	This work reports the synthesis, radiolabeling, and biological studies of Tc-99m-diethylene triamine pentaacetic acid (DTPA)-colchicine dimer in tumor-bearing mice. The novel colchicine dimer was successfully synthesized by conjugation of DTPA to 2 colchicine biomolecules. The ligand could be labeled by Tc-99m in high yield to get Tc-99m-DTPA-colchicine dimer, which was hydrophilic and stable at room temperature. Biodistribution and imaging studies in tumor-bearing mice showed that Tc-99m-DTPA-colchicine dimer accumulated in the tumor with improved uptake and retention. The results indicate the need for synthetic modification of the parent colchicine derivative and the Tc-99m-chelate with a view to improve the tumor-targeting efficacy and in vivo kinetic profiles.
电子版国际标准刊号	1099-1344
WOS关键词	PRELIMINARY BIODISTRIBUTION ; IN-VIVO ; RADIOPHARMACEUTICALS ; RESISTANCE ; AGENT ; COMPLEX
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
WOS记录号	WOS:000430669000008
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285853]
专题	高能物理研究所_核技术应用研究中心高能物理研究所_多学科研究中心
通讯作者	Wang JJ(汪建军)
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhao, QY,Yang, WJ,Zhang, YH,et al. Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,2018,61(4):395-401.
APA	Zhao, QY.,Yang, WJ.,Zhang, YH.,Xue, JQ.,Liu, Y.,...&Ma, JP.(2018).Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake.JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS,61(4),395-401.
MLA	Zhao, QY,et al."Tc-99m-labeled DTPA-colchicine dimer with improved tumor uptake".JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS 61.4(2018):395-401.