Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria

doi:10.1038/s41467-017-02502-3

	Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria
	Perez-Aguilar, JM; Li, WF; Fang, G; Chen CY(陈春英); Zhou, RH; Ge, CC; Chen, CY; Chai, ZF; Gao, XF; Shen, XM
刊名	NATURE COMMUNICATIONS
	2018
卷号	9 页码:129
ISSN号	2041-1723
DOI	10.1038/s41467-017-02502-3
文献子类	Article
英文摘要	Noble metal-based nanomaterials have shown promise as potential enzyme mimetics, but the facet effect and underlying molecular mechanisms are largely unknown. Herein, with a combined experimental and theoretical approach, we unveil that palladium (Pd) nanocrystals exhibit facet-dependent oxidase and peroxidase-like activities that endow them with excellent antibacterial properties via generation of reactive oxygen species. The antibacterial efficiency of Pd nanocrystals against Gram-positive bacteria is consistent with the extent of their enzyme-like activity, that is {100}-faceted Pd cubes with higher activities kill bacteria more effectively than {111}-faceted Pd octahedrons. Surprisingly, a reverse trend of antibacterial activity is observed against Gram-negative bacteria, with Pd octahedrons displaying stronger penetration into bacterial membranes than Pd nanocubes, thereby exerting higher antibacterial activity than the latter. Our findings provide a deeper understanding of facet-dependent enzyme-like activities and might advance the development of noble metal-based nanomaterials with both enhanced and targeted antibacterial activities.
WOS关键词	ANTIMICROBIAL AGENTS ; GOLD NANOPARTICLES ; ESCHERICHIA-COLI ; PALLADIUM NANOCRYSTALS ; SILVER NANOPARTICLES ; CATALYTIC-ACTIVITIES ; RESISTANT BACTERIA ; CARBON NANOTUBES ; ASCORBIC-ACID ; MECHANISM
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000419658100028
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/285527]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Perez-Aguilar, JM,Li, WF,Fang, G,et al. Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria[J]. NATURE COMMUNICATIONS,2018,9:129.
APA	Perez-Aguilar, JM.,Li, WF.,Fang, G.,陈春英.,Zhou, RH.,...&Chong, Y.(2018).Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria.NATURE COMMUNICATIONS,9,129.
MLA	Perez-Aguilar, JM,et al."Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria".NATURE COMMUNICATIONS 9(2018):129.