Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings

doi:10.1002/jssc.201900516

CORC > 化学研究所 > 中国科学院化学研究所

	Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings
	Liu, Lili; Qiao, Juan; Zhang, Hongyi; Qi, Li
刊名	JOURNAL OF SEPARATION SCIENCE
	2019-07-29
ISSN号	1615-9306
DOI	10.1002/jssc.201900516
英文摘要	This study developed an open-tubular capillary electrochromatography protocol for the analysis of antipyretic analgesic drugs, which used a multifunctional homopolymer as coating. A controlled/living radical polymerization strategy was adopted to obtain poly(N-acryloxysuccinimide) with a tunable chain-length. The homopolymer coating enhanced the separation performance by contributing to the hydrophobic and hydrogen-bonding interactions between the analytes and the homopolymer. The effect of polymer chain-length and buffer pH and concentration on the separation efficiency was evaluated. In this approach, baseline separation of the three test drugs was achieved within 15 min. The repeatability of the prepared homopolymer coating was investigated, with the relative standard deviations < 2.88% observed in intra- and interday runs. Good linearity in the 5-800 mu M range (R-2 >= 0.998) demonstrates that accurate quantitative analysis of real samples was achieved. Moreover, the proposed assay was used to quantify the three drugs (aminopyrine, 4-aminoantipyrine, and phenacetin) in urine samples, achieving recovery rates between 92.1 and 108.7%. This promising methodology may be used for the analysis of drugs in real bio-samples and for the development of unique homopolymer coatings for open-tubular capillary electrochromatography systems.
语种	英语
WOS记录号	WOS:000479555900001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82717]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Lili,Qiao, Juan,Zhang, Hongyi,et al. Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings[J]. JOURNAL OF SEPARATION SCIENCE,2019.
APA	Liu, Lili,Qiao, Juan,Zhang, Hongyi,&Qi, Li.(2019).Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings.JOURNAL OF SEPARATION SCIENCE.
MLA	Liu, Lili,et al."Separation of antipyretic analgesics by open tubular capillary electrochromatography with homopolymer coatings".JOURNAL OF SEPARATION SCIENCE (2019).