Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity | |
Kim, Byung-Seok1,2; Lu, Huiping3,4; Ichiyama, Kenji1; Chen, Xiang1; Zhang, Yi-Bing5; Mistry, Nipun A.6; Tanaka, Kentaro1; Lee, Young-hee1; Nurieva, Roza1; Zhang, Li7 | |
刊名 | CELL REPORTS |
2017-10-03 | |
卷号 | 21期号:1页码:195-207 |
ISSN号 | 2211-1247 |
DOI | 10.1016/j.celrep.2017.09.021 |
英文摘要 | Th17 cells are potent mediators in autoimmune diseases, and RORgt is required for their development. Recent studies have shown that ROR gamma t(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that ROR gamma t(+) Treg cells were also found in lymph nodes following immunization. Not only distinct from intestinal ROR gamma t(+) Treg cells in their transcriptomes, peripheral ROR gamma t(+) Treg cells were derived from Foxp3(+) thymic Treg cells in an antigen-specific manner. Development of these ROR gamma t(+) Treg cells, coined T regulatory 17 (Tr17) cells, depended on IL-6/Stat3 signaling. Tr17 cells showed suppressive activity against antigen-specific effector T cells in vitro. In addition, Tr17 cells efficiently inhibited myelin-specific Th17-cell-mediated CNS auto-inflammation in a passive EAE model. Collectively, our study demonstrates that Tr17 cells are effector Treg cells that potentially restrict autoimmunity. |
资助项目 | NIH[R01AR050772] ; Cancer Prevention and Research Institute of Texas[RP130078] ; Department of Defense[W81XWH-16-1-0100] ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education[2016R1A6A3A11933284] ; Arthritis Foundation of the United States[6128] |
WOS关键词 | ROR-GAMMA-T ; REMITTING MULTIPLE-SCLEROSIS ; HELPER-CELLS ; T-H-17 CELLS ; CCR6 ; DIFFERENTIATION ; TRANSCRIPTION ; EXPRESSION ; INFLAMMATION ; SUPPRESSION |
WOS研究方向 | Cell Biology |
语种 | 英语 |
出版者 | CELL PRESS |
WOS记录号 | WOS:000412111000017 |
资助机构 | NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Cancer Prevention and Research Institute of Texas ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Department of Defense ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States ; Arthritis Foundation of the United States |
内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/32722] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Chang, Seon Hee; Dong, Chen |
作者单位 | 1.MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77054 USA 2.Seoul Natl Univ, Coll Pharm, Lab Immune Regulat, Seoul 08826, South Korea 3.Tsinghua Univ, Inst Immunol, Beijing 100084, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 6.MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77054 USA 7.Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45219 USA 8.Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA |
推荐引用方式 GB/T 7714 | Kim, Byung-Seok,Lu, Huiping,Ichiyama, Kenji,et al. Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity[J]. CELL REPORTS,2017,21(1):195-207. |
APA | Kim, Byung-Seok.,Lu, Huiping.,Ichiyama, Kenji.,Chen, Xiang.,Zhang, Yi-Bing.,...&Dong, Chen.(2017).Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity.CELL REPORTS,21(1),195-207. |
MLA | Kim, Byung-Seok,et al."Generation of ROR gamma t(+) Antigen-Specific T Regulatory 17 Cells from Foxp3(+) Precursors in Autoimmunity".CELL REPORTS 21.1(2017):195-207. |
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