Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition

doi:10.1002/slct.201600907

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 淡水生态学研究中心 > 期刊论文

	Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition
	Luo, Qiang 1,2; Wang, Zhaokai 3; Chen, Huibin 3; Fang, Hui 3; Xie, Shouqi 2; Qian, Xueqiao 1; Lin, Xiangzhi 3
刊名	CHEMISTRYSELECT
	2016-08-16
卷号	1 期号:13 页码:3909-3913
关键词	natural products nuclear receptor RXR alpha erythrotriol tumor
ISSN号	2365-6549
DOI	10.1002/slct.201600907
通讯作者	Luo, Qiang(luoqiangharry@126.com) ; Lin, Xiangzhi(xzlin@tio.org.cn)
英文摘要	Natural products (NP), especially medicinal plants, have been used worldwide to treat numerous diseases for thousands of years. However, drug discovery focus has been moving away from identifying lead compounds from complex mixtures of crude NP because this approach is technically difficult and inefficient. We here present a quick, accurate and practical method for screening leads targeting a nuclear receptor from NP mixtures. Using the method, we rapidly identified erythrotriol as a new lead compound from medicinal plant Hibiscus syriacus L. targeting RXR alpha for treating cancer with less side effects. This method can efficiently and profitably screen lead compounds targeting nuclear receptors and may reinvigorate interest in NP as sources of pharmaceutical agents.
资助项目	Regional Demonstration of Marine Economy Innovative Development Project[12PYY001SF08] ; National Natural Science Foundation of China[31401564] ; Marine High-technology Industry of the Fujian Province[[2013]30] ; Marine High-technology Industry of the Fujian Province[[2014]23]
WOS关键词	T-CELL LYMPHOMA ; RXR-ALPHA ; DISCOVERY ; BEXAROTENE ; PARTNERS ; CANCER ; SUPERFAMILY ; MODULATORS ; CHEMISTRY ; HONOKIOL
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000392302300075
资助机构	Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; Regional Demonstration of Marine Economy Innovative Development Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province ; Marine High-technology Industry of the Fujian Province
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/33110]
专题	水生生物研究所_淡水生态学研究中心_期刊论文
通讯作者	Luo, Qiang; Lin, Xiangzhi
作者单位	1.Guangdong Haid Grp Co Ltd, Anim Husb & Fisheries Res Ctr, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China 3.State Ocean Adm, Inst Oceanog 3, Engn Res Ctr Marine Biol Resource Comprehens Util, Xiamen, Peoples R China
推荐引用方式 GB/T 7714	Luo, Qiang,Wang, Zhaokai,Chen, Huibin,et al. Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition[J]. CHEMISTRYSELECT,2016,1(13):3909-3913.
APA	Luo, Qiang.,Wang, Zhaokai.,Chen, Huibin.,Fang, Hui.,Xie, Shouqi.,...&Lin, Xiangzhi.(2016).Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition.CHEMISTRYSELECT,1(13),3909-3913.
MLA	Luo, Qiang,et al."Identification of Anticancer Drug Candidate Targeting Nuclear Receptor Retinoid X receptor-alpha from Natural Products using Receptor-Ligand Recognition".CHEMISTRYSELECT 1.13(2016):3909-3913.