Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish | |
Dai, Xiangyan1; Shu, Yuqin2,3; Lou, Qiyong2; Tian, Qiang1; Zhai, Gang2; Song, Jia2,3; Lu, Suxiang2,3; Yu, Hong1; He, Jiangyan2; Yin, Zhan2 | |
刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2017-06-01 | |
卷号 | 18期号:6页码:20 |
关键词 | tdrd12 knockout germ cell differentiation maintenance zebrafish |
ISSN号 | 1422-0067 |
DOI | 10.3390/ijms18061127 |
英文摘要 | The regularity of Piwi-interacting RNA (piRNA) biogenesis is crucial to germline development. Functioning as Piwi-interacting proteins, Tudor domain-related proteins (Tdrds) have been demonstrated to be involved in spermatogenesis and the piRNA pathway. In this study, zebrafish tdrd12 was identified, and the maternal and germ cell-specific expression patterns of zebrafish tdrd12 were observed. Utilizing TALEN (transcription activator-like effector nuclease) techniques, two independent tdrd12 mutant zebrafish lines were generated. Although no defects were found during the generation of the primordial germ cells (PGCs) in the tdrd12-null fish progenies obtained from the heterozygous tdrd12 mutant parents, all Tdrd12-deficient fish developed into infertile males. The reduced numbers and eventually loss of the germ cells by 35 days post fertilization (dpf) led to masculinization and infertility of the Tdrd12-deficient fish. Meiosis defects of the germ cells in the tdrd12 mutants during the gonad-transitioning period were observed, revealing the indispensable functions of Tdrd12 in gametogenesis. Our studies demonstrated that zebrafish Tdrd12 is essential for germ cell development and maintenance. |
资助项目 | National Natural Science Foundation of China[31530077] ; National Basic Research Program of China (973 Program)[2014CB138602] |
WOS关键词 | DOMAIN-CONTAINING PROTEINS ; TUDOR-RELATED GENE ; SEX DETERMINATION ; PIRNA BIOGENESIS ; PIWI PROTEINS ; MOLECULAR SCAFFOLD ; DIFFERENTIATION ; MICE ; EXPRESSION ; SPERMATOGENESIS |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | MDPI AG |
WOS记录号 | WOS:000404581500027 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; 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内容类型 | 期刊论文 |
源URL | [http://ir.ihb.ac.cn/handle/342005/32518] |
专题 | 水生生物研究所_中科院水生所知识产出(2009年前) |
通讯作者 | Yin, Zhan |
作者单位 | 1.Southwest Med Univ, Dept Med Cell Biol & Genet, Coll Preclin Med, Luzhou 646000, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Dai, Xiangyan,Shu, Yuqin,Lou, Qiyong,et al. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(6):20. |
APA | Dai, Xiangyan.,Shu, Yuqin.,Lou, Qiyong.,Tian, Qiang.,Zhai, Gang.,...&Yin, Zhan.(2017).Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(6),20. |
MLA | Dai, Xiangyan,et al."Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.6(2017):20. |
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