Highly Enantioselective Construction of Spiro[4H-pyran-3,3 '-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

	Highly Enantioselective Construction of Spiro[4H-pyran-3,3 '-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine
	Chen, Wen-Bing ; Wu, Zhi-Jun ; Pei, Qing-Lan ; Cun, Lin-Feng ; Zhang, Xiao-Mei ; Yuan, Wei-Cheng
刊名	ORGANIC LETTERS
	2010
卷号	12 期号:14 页码:3132-3135
ISSN号	1523-7060
通讯作者	Yuan, WC, Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
产权排序	3
中文摘要	The first enantioselective organocatalytic two- and three-component reactions via a domino Knoevenagel/Michael/cyclization sequence with cupreine as catalyst have been developed. A wide range of optically active spiro[4H-pyran-3,3'-oxindoles] were obtained in excellent yields (up to 99%) with good to excellent enantioselectivities (up to 97%) from simple and readily available starting materials under mild reaction conditions. These heterocyclic spirooxindoles will provide promising candidates for chemical biology and drug discovery.
学科主题	Chemistry, Organic
收录类别	SCI
资助信息	NSFC [20802074]; National Basic Research Program of China (973 Program) [2010CB833300]
语种	英语
WOS记录号	WOS:000279569600005
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18401]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Chen, Wen-Bing,Wu, Zhi-Jun,Pei, Qing-Lan,et al. Highly Enantioselective Construction of Spiro[4H-pyran-3,3 '-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine[J]. ORGANIC LETTERS,2010,12(14):3132-3135.
APA	Chen, Wen-Bing,Wu, Zhi-Jun,Pei, Qing-Lan,Cun, Lin-Feng,Zhang, Xiao-Mei,&Yuan, Wei-Cheng.(2010).Highly Enantioselective Construction of Spiro[4H-pyran-3,3 '-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine.ORGANIC LETTERS,12(14),3132-3135.
MLA	Chen, Wen-Bing,et al."Highly Enantioselective Construction of Spiro[4H-pyran-3,3 '-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine".ORGANIC LETTERS 12.14(2010):3132-3135.