Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine

	Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine
	Tao, FY ; Luo, YG ; Huang, QC ; Liu, Y ; Li, BG ; Zhang, GL
刊名	AMINO ACIDS
	2009
卷号	37 期号:4 页码:603_607
关键词	L-beta-Haloalanine Cysteine Cystine Halogenation Desulfurization Functional group transformation
ISSN号	0939-4451
通讯作者	Luo, YG, Chinese Acad Sci, Chengdu Inst Biol, Ctr Nat Prod Res, Chengdu 610041, Peoples R China.
产权排序	1
中文摘要	l-beta-Haloalanines are physiologically active unnatural amino acids and they are useful intermediates for the synthesis of natural and unnatural amino acids, S-linked glycopeptides, and lanthionines. In general l-beta-haloalanines were prepared predominantly from l-serine via functional group transformation. Here we reported an alternative approach for the preparation of l-beta-haloalanines via halogenation of protected l-cysteine esters which was obtained from l-cysteine or l-cystine, respectively. The mercapto group of protected l-cysteine esters was efficiently transformed to halo groups by triphenylphosphine/N-halosuccinimides. It has been proved to be a versatile desulfurization strategy via this functional group transformation.
学科主题	Biochemistry & Molecular Biology
收录类别	SCI
资助信息	Chinese Academy of Sciences
语种	英语
WOS记录号	WOS:000270280400007
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/18243]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	Tao, FY,Luo, YG,Huang, QC,et al. Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine[J]. AMINO ACIDS,2009,37(4):603_607.
APA	Tao, FY,Luo, YG,Huang, QC,Liu, Y,Li, BG,&Zhang, GL.(2009).Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine.AMINO ACIDS,37(4),603_607.
MLA	Tao, FY,et al."Facile syntheses of l-beta-haloalanine derivatives from l-cysteine or l-cystine".AMINO ACIDS 37.4(2009):603_607.