Effective activation of the chiral salen/Ti(OiPr)(4) catalyst with achiral phenolic N-oxides as additives in the enantioselective cyanosilylation of ketones

	Effective activation of the chiral salen/Ti(OiPr)(4) catalyst with achiral phenolic N-oxides as additives in the enantioselective cyanosilylation of ketones
	He, B ; Chen, FX ; Li, Y ; Feng, XM ; Zhang, GL
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2004
期号	22 页码:4657_4666
关键词	asymmetric catalysis N-oxides cyanosilylation cyanohydrins
ISSN号	1434-193X
通讯作者	He, B, Sichuan Univ, Coll Chem, Key LGreen Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China.
产权排序	3
中文摘要	The activation of chiral titanium(IV) complexes with phenolic N-oxides additives has been found to provide an alternative strategy for the asymmetric cyanosilylation of ketones. By using 10 mol % of chiral salen-titanium(IV) complex in combination with 1 mol% achiral phenolic N-oxide as an additive, aromatic, aliphatic and heterocyclic ketones have been converted into the corresponding cyanohydrin trimethylsilyl ethers in 58-96% yields with 56-82% ee. Several factors concerning the reactivity and enantioselectivity have been discussed. A catalytic cycle based on experimental phenomena and studies has been proposed to explain the origin of this activation and the asymmetric induction.
学科主题	Chemistry, Organic
收录类别	SCI
语种	英语
WOS记录号	WOS:000225420600018
公开日期	2011-07-08
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/17497]
专题	成都生物研究所_天然产物研究
推荐引用方式 GB/T 7714	He, B,Chen, FX,Li, Y,et al. Effective activation of the chiral salen/Ti(OiPr)(4) catalyst with achiral phenolic N-oxides as additives in the enantioselective cyanosilylation of ketones[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2004(22):4657_4666.
APA	He, B,Chen, FX,Li, Y,Feng, XM,&Zhang, GL.(2004).Effective activation of the chiral salen/Ti(OiPr)(4) catalyst with achiral phenolic N-oxides as additives in the enantioselective cyanosilylation of ketones.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(22),4657_4666.
MLA	He, B,et al."Effective activation of the chiral salen/Ti(OiPr)(4) catalyst with achiral phenolic N-oxides as additives in the enantioselective cyanosilylation of ketones".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .22(2004):4657_4666.