QQ客服 官方微博 反馈留言

	Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
	Yoon, WD; Kim, DK; Kim, E; Liu, YH; Jung, JH; jhjung@pusan.ac.kr; La Kim, E; Li, JL; Dang, HT; Hong, J
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2012
卷号	22期号:9页码:3126-3129
关键词	Cytochalasin Jellyfish-derived Fungus Phoma Sp. Nemopilema Nomurai Cytotoxicity
ISSN号	0960-894X
英文摘要	Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic
资助项目	LMB
语种	英语
WOS记录号	WOS:000302964300017
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9924]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	jhjung@pusan.ac.kr
推荐引用方式 GB/T 7714	Yoon, WD,Kim, DK,Kim, E,et al. Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3126-3129.
APA	Yoon, WD.,Kim, DK.,Kim, E.,Liu, YH.,Jung, JH.,...&Lee, CO.(2012).Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3126-3129.
MLA	Yoon, WD,et al."Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3126-3129.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。