Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity
	liqx81@163.com; zhsimd@scsio.ac.cn; tj6188@sina.com; lq_11@hotmail.com; yinhao@scsio.ac.cn; whhe@scsio.ac.cn; luoxm163@sina.com; Zhang, S; Huang, YZ; Liu, Q
刊名	MOLECULES
	2012
卷号	17 期号:6 页码:6944-6952
关键词	Micromelum Falcatum Coumarins Brine Shrimp Larvae Toxicity Cytotoxicity Antibacterial Activity
ISSN号	1420-3049
英文摘要	Two new coumarins, 7-methoxy-8-(2-hydroxmethyl-1-O-isovaleryl-4-butenyl)coumarin (1) and 7-methoxy-8-(1-hydroxy-2-O-beta-glucopyranosyl-3-methyl-4-butene-1-yl) coumarin (2), and twelve known coumarins 3-14 were isolated from the stem bark of Micromelum falcatum. The structures of compounds 1-14 were elucidated by extensive spectroscopic data analyses. The toxicity of compounds 1-14 was tested using a brine shrimp assay and in vitro antiproliferative assay against mammary cancer (F10) and lung cancer (HvEvc) cell lines by the MTT method. Some compounds had moderate activities. All compounds were also tested against the microorganisms Bacillus subtilis, Bacillus thuringiensis and Escherichia coli, but no activity was observed.
学科主题	Chemistry, Organic
资助项目	LMB
语种	英语
WOS记录号	WOS:000305800400052
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/9884]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	liqx81@163.com; zhsimd@scsio.ac.cn; tj6188@sina.com; lq_11@hotmail.com; yinhao@scsio.ac.cn; whhe@scsio.ac.cn; luoxm163@sina.com
推荐引用方式 GB/T 7714	liqx81@163.com,zhsimd@scsio.ac.cn,tj6188@sina.com,et al. Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity[J]. MOLECULES,2012,17(6):6944-6952.
APA	liqx81@163.com.,zhsimd@scsio.ac.cn.,tj6188@sina.com.,lq_11@hotmail.com.,yinhao@scsio.ac.cn.,...&Luo, XM.(2012).Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity.MOLECULES,17(6),6944-6952.
MLA	liqx81@163.com,et al."Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity".MOLECULES 17.6(2012):6944-6952.