An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells

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	An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells
	tanglan_tongji@hotmail.com; Zhou, XF; Tang, L; Liu, YH; zhou-xuefeng@hotmail.com
刊名	LIPIDS
	2009
卷号	44 期号:8 页码:759-763
关键词	Soya-cerebrosides Mixture Of Cerebrosides Interleukin-18 Cytotoxicity Peripheral Blood Mononuclear Cells
ISSN号	0024-4201
英文摘要	An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 mu M, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug.
学科主题	Biochemistry & Molecular Biology ; Nutrition & Dietetics
URL标识	查看原文
资助项目	LMB
WOS记录号	WOS:000268301900009
公开日期	2011-07-03
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/5094]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	tanglan_tongji@hotmail.com; zhou-xuefeng@hotmail.com
推荐引用方式 GB/T 7714	tanglan_tongji@hotmail.com,Zhou, XF,Tang, L,et al. An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells[J]. LIPIDS,2009,44(8):759-763.
APA	tanglan_tongji@hotmail.com,Zhou, XF,Tang, L,Liu, YH,&zhou-xuefeng@hotmail.com.(2009).An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells.LIPIDS,44(8),759-763.
MLA	tanglan_tongji@hotmail.com,et al."An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells".LIPIDS 44.8(2009):759-763.