Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399

doi:10.1038/s41429-018-0103-6

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
	Cong, Ziwen 1; Wang, Junfeng ; Huang, Dongyi 1; Zhou, Xuefeng ; Yang, Bin ; Liao, Shengrong ; Wang, Pei 2; Liu, Yuxuan ; Liu, Yunhao ; Huang, Xiaolong 1
刊名	JOURNAL OF ANTIBIOTICS
	2019
卷号	72 期号:1 页码:45
ISSN号	0021-8820
DOI	10.1038/s41429-018-0103-6
英文摘要	Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17929]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China 2.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China 3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China
推荐引用方式 GB/T 7714	Cong, Ziwen,Wang, Junfeng,Huang, Dongyi,et al. Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399[J]. JOURNAL OF ANTIBIOTICS,2019,72(1):45, 49.
APA	Cong, Ziwen.,Wang, Junfeng.,Huang, Dongyi.,Zhou, Xuefeng.,Yang, Bin.,...&Huang, Xiaolong.(2019).Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399.JOURNAL OF ANTIBIOTICS,72(1),45.
MLA	Cong, Ziwen,et al."Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399".JOURNAL OF ANTIBIOTICS 72.1(2019):45.