Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452

doi:10.3389/fchem.2019.00350

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	Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452
	Zhang, Weimin 4; Zhong, Weimao 1; Fu, Tingdan 3; Wei, Xiaoyi 2; Chen, Yuchan 4; Wang, Junfeng ; Zeng, Qi 1; Wang, Fazuo ; Long, Lijuan ; Zhang, Si
刊名	FRONTIERS IN CHEMISTRY
	2019
卷号	7 页码:350
关键词	Eurotium sp. SCSIO F452 spirocyclic alkaloid enantiomers antioxidative and cytotoxic activities Diels-Alder cycloaddition molecular docking
ISSN号	2296-2646
DOI	10.3389/fchem.2019.00350
英文摘要	Three pairs of new spirocyclic alkaloid enantiomers eurotinoids A-C (1-3), as well as a known biogenetically related racemate dihydrocryptoechinulin D (4) were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures were determined by spectroscopic analyses and electronic circular dichroism(ECD) calculations. Compounds 1 and 2 represent the first two "meta" products from a non-stereoselective [4 + 2] Diels-Alder cycloaddition presumably between an enone group of a diketopiperazine alkaloid and a diene group of a benzaldehyde derivative via a new head-to-tail coupling mode biosynthetically, while 3 and 4 were "ortho" products. Their enantiomers exhibited different antioxidative and cytotoxic activities. The modes of action were investigated by a preliminary molecular docking study.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17843]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou, Guangdong, Peoples R China 4.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou, Guangdong, Peoples R China 5.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Weimin,Zhong, Weimao,Fu, Tingdan,et al. Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452[J]. FRONTIERS IN CHEMISTRY,2019,7:350.
APA	Zhang, Weimin.,Zhong, Weimao.,Fu, Tingdan.,Wei, Xiaoyi.,Chen, Yuchan.,...&Huang, Xinan.(2019).Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452.FRONTIERS IN CHEMISTRY,7,350.
MLA	Zhang, Weimin,et al."Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452".FRONTIERS IN CHEMISTRY 7(2019):350.