New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060

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	New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060
	Zhang, Changsheng ; Zhang, Guangtao ; Zhang, Wenjun ; Zhang, Liping ; Liu, Wei 2; Jiang, Xiaodong 3; Jin, Hongbo 3; Liu, Zhiwen ; Zhang, Haibo ; Zhou, Aihua 1
刊名	TETRAHEDRON
	2018
卷号	74 期号:47 页码:6839
关键词	Marine-derived Streptomyces sp SCSIO 40060 Genome mining Polycyclic tetramate macrolactams Absolute structure
ISSN号	0040-4020
英文摘要	Polycyclic tetramate macrolactams (PTMs) are widely distributed in nature and are generated from a compact biosynthetic pathway. Bioinformatics analysis of the draft genome sequence of marine-derived Streptomyces sp. SCSIO 40060 revealed the presence of a putative PTM-encoding biosynthetic gene cluster (BGC). Comparison of this PTM BGC with those from the databank by genome mining suggests that Streptomyces sp. SCSIO 40060 should produce PTMs with a 5/6/5 type of carbocyclic ring. Subsequently, a 40-L scale of cultivation of Streptomyces sp. SCSIO 40060 led to the isolation and characterization of four known PTMs, ikarugamycin (1), epoxyikarugamycin (2), capsimycin (3), capsimycin C (4), and three new PTMs, hydroxyikarugamycins A-C (5-7). The planar structures of 5-7 were assigned by comprehensive spectroscopic analysis and the absolute configurations of 5 and 6 were unequivocally determined by X-ray diffraction analysis. The absolute structure of 7 was deduced by comparing ECD spectra of 5-7. Capsimycin (3) showed antimicrobial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 16 mu g/mL and displayed cytotoxicity against several cancer cell lines with IC50 values ranging from 2.62 to 6.87 mu M. (C) 2018 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17605]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.South China Sea Resource Exploitat & Protect Coll, State Key Lab Appl Microbiol Southern China, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,CAS Key Lab Trop Marine, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 4.Jiangsu Univ, Pharm Sch, Xuefu Rd 301, Zhenjiang City 212013, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Changsheng,Zhang, Guangtao,Zhang, Wenjun,et al. New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060[J]. TETRAHEDRON,2018,74(47):6839, 6845.
APA	Zhang, Changsheng.,Zhang, Guangtao.,Zhang, Wenjun.,Zhang, Liping.,Liu, Wei.,...&Zhou, Aihua.(2018).New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060.TETRAHEDRON,74(47),6839.
MLA	Zhang, Changsheng,et al."New polycyclic tetramate macrolactams from marine-derived Streptomyces sp SCSIO 40060".TETRAHEDRON 74.47(2018):6839.