Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death

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	Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death
	Lu, Yishan 1,4; Cai, Jia 1,4; Jian, Jichang 1,4; Qin, Qiwei 2; Zheng, Qi 1,4; Ji, Huasong 3; Wei, Shina 2; Tang, Jufen 1,4
刊名	FISH & SHELLFISH IMMUNOLOGY
	2018
卷号	83 页码:436
关键词	Epinephelus coioides Bcl-xL Singapore grouper iridovirus (SGIV) Viral gene Nonapoptotic cell death
ISSN号	1050-4648
英文摘要	Bcl-2 family proteins play essential roles in modulating immune response and controlling cells' fate. Bcl-xL is one of anti-apoptotic protein in this family. In this study, a new Bcl-xL homolog (EcBcl-xL) was identified and characterized from orange-spotted grouper, Epinephelus coioides. EcBcl-xL encoded a 221 amino acid peptides that shared 86% identity to Larimichthys crocea Bcl-xL protein, contained four conserved BH domains and one transmembrane region. The predicted three-dimensional structure of EcBcl-xL was similar with Homo sapiens BclxL. EcBcl-xL widely expressed in all tested tissues with highest expression in head kidney. Its expression level was significantly up-regulated after SGIV infection in vivo. Furthermore, overexpression of EcBcl-xL could inhibit SGIV-induced nonapoptotic cell death and suppressed viral genes transcriptions in GS cells. Our findings suggested that EcBcl-xL might play a role during virus infection through modulating SGIV-induced nonapoptotic cell death.
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17600]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位	1.Guangdong Ocean Univ, Coll Fishery, Zhanjiang 524088, Peoples R China 2.Guangdong Key Lab Control Dis Aquat Econ Anim, Zhanjiang 524088, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 4.Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang 524088, Peoples R China 5.Zhaoqing Dahuanong Biol Med Co Ltd, Zhaoqing, Peoples R China
推荐引用方式 GB/T 7714	Lu, Yishan,Cai, Jia,Jian, Jichang,et al. Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death[J]. FISH & SHELLFISH IMMUNOLOGY,2018,83:436, 442.
APA	Lu, Yishan.,Cai, Jia.,Jian, Jichang.,Qin, Qiwei.,Zheng, Qi.,...&Tang, Jufen.(2018).Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death.FISH & SHELLFISH IMMUNOLOGY,83,436.
MLA	Lu, Yishan,et al."Identification of a Bcl-xL homolog from orange-spotted grouper (Epinephelus coioides) involved in SGIV-induced nonapoptotic cell death".FISH & SHELLFISH IMMUNOLOGY 83(2018):436.