| Mechanisms, function and clinical applications of DNp73 | |
| Di, Cuixia1,3,4; Yang, Lina2; Zhang, Hong1,3,4; Ma, Xiaofei1,3,4; Zhang, Xin1,3,4; Sun, Chao1,3,4; Li, Hongyan1,3,4; Xu, Shuai1,3,4; An, Lizhe2; Li, Xun5 | |
| 刊名 | CELL CYCLE
 |
| 2013-06-15 | |
| 卷号 | 12期号:12页码:1861-1867 |
| 关键词 | DNp73 alternative splicing apoptosis cancer chemosensitivity radiotherapy tumorigenesis |
| ISSN号 | 1538-4101 |
| DOI | 10.4161/cc.24967 |
| 通讯作者 | Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | p73, has two distinct promoters, which allow the formation of two protein isoforms: full-length transactivating (TA) p73 and an N-terminally truncated p73 species (referred to as DNp73) that lacks the N-terminal transactivating domain. Although the exact cellular function of DNp73 is unclear, the high expression levels of the genes have been observed in a variety of human cancers and cancer cell lines and have been connected to pro-tumor activities. Hence the aim of this review is to summarize DNp73 expression status in cancer in the current literature. Furthermore, we also focused on recent findings of DNp73 related to the biological functions from apoptosis, chemosensitivity, radiosensitibity, differentiation, development, etc. Thus this review highlights the significance of DNp73 as a marker for disease severity in patients and as target for cancer therapy. |
| 收录类别 | SCI |
| WOS关键词 | CERVICAL-CANCER CELLS ; P53 FAMILY ; TUMOR-SUPPRESSOR ; IN-VIVO ; OVARIAN-CANCER ; LUNG-CANCER ; DNA-DAMAGE ; HEPATOCELLULAR-CARCINOMA ; DELTA-NP73 EXPRESSION ; NEURONAL SURVIVAL |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | LANDES BIOSCIENCE |
| WOS记录号 | WOS:000323170200017 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2557856 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China 5.Lanzhou Univ, Hosp 1, Dept Gen Surg 2, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Di, Cuixia,Yang, Lina,Zhang, Hong,et al. Mechanisms, function and clinical applications of DNp73[J]. CELL CYCLE,2013,12(12):1861-1867. |
| APA | Di, Cuixia.,Yang, Lina.,Zhang, Hong.,Ma, Xiaofei.,Zhang, Xin.,...&Bai, Zhongtian.(2013).Mechanisms, function and clinical applications of DNp73.CELL CYCLE,12(12),1861-1867. |
| MLA | Di, Cuixia,et al."Mechanisms, function and clinical applications of DNp73".CELL CYCLE 12.12(2013):1861-1867. |
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