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	Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells
	Zhang, Qianjing1,2,3; Di, Cuixia1,2,3; Yan, Junfang1,2,3; Wang, Fang1,2,3; Qu, Tao4; Wang, Yupei1,2,3; Chen, Yuhong1,2,3; Zhang, Xuetian1,2,3; Liu, Yang1,2,3; Yang, Hongying5
刊名	ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
	2019
卷号	47期号:1页码:1273-1280
关键词	Alternative splicing apoptosis cancer pladienolide B p73 SF3b1
ISSN号	2169-1401
DOI	10.1080/21691401.2019.1596922
通讯作者	Zhang, Hong(zhang.h@impcas.ac.cn)
英文摘要	Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the spliceosome. There is considerable interest in the compound as a tool to study SF3b1 function in cancer. However, so far little information is available on the molecular mechanism of SF3b1 eliciting apoptosis in cancer cells. Here, we investigated the molecular mechanism of SF3b1 eliciting apoptosis in human cervical carcinoma cells. We demonstrated that inhibition of SF3b1 by pladienolide B inhibited proliferation of HeLa cells at low nanomolar concentrations in a dose- and time-dependent manner. It also induced G2/M phase arrest and significant rise of apoptotic cells. Moreover, it is indicated that inhibition of SF3b1 by pladienolide B induced Tap73/Delta Np73 expression and consequently down-regulated Bax/Bcl-2 ratio, cytochrome c release and caspase-3 expression. Thus, our results showed that SF3b1 plays a pivotal role in cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells, suggesting that SF3b1 could be used as a potential candidate for cervical cancer therapy.
收录类别	SCI
WOS关键词	IN-VITRO ; TARGET ; CANCER ; PATHWAY ; TAP73/DELTA-NP73 ; SPLICEOSOME ; PROGNOSIS ; PROTEINS ; RATIO ; LIFE
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS类目	Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000463887200001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2555491
专题	寒区旱区环境与工程研究所
通讯作者	Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Sch Life Sci, Beijing, Peoples R China 4.Gansu Prov Hosp, Dept Biotherapy Ctr, Lanzhou, Gansu, Peoples R China 5.Soochow Univ, Med Coll Soochow, Med Sch Radiat Med & Protect, Suzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qianjing,Di, Cuixia,Yan, Junfang,et al. Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2019,47(1):1273-1280.
APA	Zhang, Qianjing.,Di, Cuixia.,Yan, Junfang.,Wang, Fang.,Qu, Tao.,...&Zhang, Hong.(2019).Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,47(1),1273-1280.
MLA	Zhang, Qianjing,et al."Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 47.1(2019):1273-1280.

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