Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property

doi:10.1016/j.colsurfa.2019.04.060

	Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property
	Wang, Shengtao 1,2; Li, Jingtao 3; Ye, Zhou 1; Li, Jieling 2; Wang, Anhe 2; Hu, Jing 1; Bai, Shuo 2; Yin, Jian 1
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2019-08-05
卷号	574 页码:44-51
关键词	Nanoparticles Self-assembly Combined therapy Real-time tracing Cancer treatment
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2019.04.060
英文摘要	Herein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes effectively solves the problem of low drug loading efficiency and difficulty in drug release. Meanwhile, with the assistance of the photochemical internalization effect more carriers are taken up and accumulate in the cancer cells. Moreover, the auto-fluorescence of BODIPY can trace and visualize the carriers in cells or tissues and the damage of reactive oxygen species (ROS) to the multidrug resistance (MDR) transporter proteins can overcome MDR in cancer chemotherapy. The IC50 of PEGylated BODIPY is 250 mu g/mL while the IC(50 )decreased to 100 mu g/mL for Dox@ PEGylated BODIPY. As shown in our experiment the self-carriers itself without loading other bioactive constituents can obviously inhibit the growth of cancer cells, and the therapeutic effect is improved after the loading of Dox, indicating the amphipathic polymeric photosensitizer with tracing and self-assembling properties a potential multifunctional cancer treatment platform.
资助项目	National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21877052] ; National Natural Science Foundation of China[31700706] ; Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; State Key Laboratory of Biochemical Engineering[2019KF-02] ; Max Planck Society International Partner Group Program
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; RESPONSIVE NANOCARRIERS ; MULTIDRUG-RESISTANCE ; HIGHLY EFFICIENT ; CARRIER-FREE ; CO-DELIVERY ; COMBINATION ; DOXORUBICIN ; CONJUGATE ; MICELLES
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000471654700006
资助机构	National Natural Science Foundation of China ; Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; State Key Laboratory of Biochemical Engineering ; Max Planck Society International Partner Group Program
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/29981]
专题	中国科学院过程工程研究所
通讯作者	Bai, Shuo; Yin, Jian
作者单位	1.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shengtao,Li, Jingtao,Ye, Zhou,et al. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,574:44-51.
APA	Wang, Shengtao.,Li, Jingtao.,Ye, Zhou.,Li, Jieling.,Wang, Anhe.,...&Yin, Jian.(2019).Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,574,44-51.
MLA	Wang, Shengtao,et al."Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 574(2019):44-51.