alpha-shaped DNA loops induced by MutS

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	alpha-shaped DNA loops induced by MutS
	Jia, YX; Bi, LJ; Li, F; Chen, YY; Zhang, CG; Zhang, XE; Zhang, XE, Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2008
卷号	372 期号:4 页码:618-622
关键词	Mmr Muts Mismatch Alpha-loop
ISSN号	0006-291X
英文摘要	DNA mismatch repair (MMR) is critical for the maintenance of genomic stability. MMR is initiated by recognition of DNA mismatches by the protein, MutS, which subsequently recruits downstream repair factors. To better understand the mechanism by which MutS identifies and specifically binds mismatched basepairs embedded in random DNA sequences, we monitored the interaction between MutS and DNA substrates using atomic force microscopy (AFM). An alpha-shaped DNA loop formed by the interaction between MutS and DNA, which was independent of whether or not a mismatch was present in the DNA substrate. These data indicate that MutS associates with DNA non-specifically and forms an alpha-loop interaction with the DNA substrate. in this conformation, MutS is able to scan two arms of DNA simultaneously for each MutS dimer formed. (C) 2008 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
语种	英语
WOS记录号	WOS:000257419500020
公开日期	2011-09-23
内容类型	期刊论文
源URL	[http://210.72.129.5/handle/321005/54445]
专题	沈阳应用生态研究所_沈阳应用生态研究所
通讯作者	Zhang, XE, Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Jia, YX,Bi, LJ,Li, F,et al. alpha-shaped DNA loops induced by MutS[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,372(4):618-622.
APA	Jia, YX.,Bi, LJ.,Li, F.,Chen, YY.,Zhang, CG.,...&Zhang, XE, Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China.(2008).alpha-shaped DNA loops induced by MutS.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,372(4),618-622.
MLA	Jia, YX,et al."alpha-shaped DNA loops induced by MutS".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372.4(2008):618-622.