Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes)

doi:10.1002/etc.3112

	Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes)
	Li, Lixia; Chen, Hongxing; Bi, Ran; Xie, Lingtian
刊名	ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
	2015-11-01
卷号	34 期号:11 页码:2611-2617
关键词	Chromium Bioaccumulation Subcellular Distribution Acute Effects Japanese Medaka
ISSN号	0730-7268
DOI	10.1002/etc.3112
英文摘要	Chromium (Cr) is an essential element but is toxic to aquatic organisms at elevated concentrations. In the present study, adult Japanese medaka (Oryzias latipes) were exposed to a sublethal hexavalent chromium (Cr(VI)) concentration via dissolved and dietary exposures for 6d. Various measurements of Cr were made: bioaccumulation in different tissues, subcellular distribution in the liver, effects on antioxidants and acetylcholinesterase (AChE), and Cr-induced lipid peroxidation. The results showed that bioaccumulation increased dramatically in all tested tissues from dissolved exposure but only significantly in the intestine from dietary treatment, implying that dissolved exposure may be predominant for Cr accumulation in medaka. Subcellular distribution revealed that Cr accumulated in the liver was mainly (46%) associated with the heat-stable protein fraction. Among the antioxidants examined, catalase (CAT) responded to dissolved Cr exposure in most tissues whereas superoxide dismutase (SOD) was less responsive. Malondialdehyde concentrations were significantly elevated in most tissues examined in the dissolved Cr-exposed fish, but were only elevated in the liver and intestine in the dietary Cr-exposed fish. The AChE activity in the brain was stimulated by 49% in the dissolved Cr-exposed fish. Reductions in condition factor and gonadosomatic index were also observed. These data help in an understanding of Cr tissue distribution and the acute effects of Cr in Japanese medaka. Environ Toxicol Chem 2015;34:2611-2617. (c) 2015 SETAC
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000363706100024
内容类型	期刊论文
源URL	[http://210.72.129.5/handle/321005/122255]
专题	中国科学院沈阳应用生态研究所
通讯作者	Xie, Lingtian
作者单位	Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Dalian, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Li, Lixia,Chen, Hongxing,Bi, Ran,et al. Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes)[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2015,34(11):2611-2617.
APA	Li, Lixia,Chen, Hongxing,Bi, Ran,&Xie, Lingtian.(2015).Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes).ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,34(11),2611-2617.
MLA	Li, Lixia,et al."Bioaccumulation, subcellular distribution, and acute effects of chromium in Japanese medaka (Oryzias latipes)".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 34.11(2015):2611-2617.