Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base

doi:10.3390/catal9030278

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base
	Shi, Xiaolin 1,2,4; Li, Xiaowei1,2,4 ; Ma, Lina 1,2,4; Shi, Dayong 1,2,3,4
刊名	CATALYSTS
	2019-03-01
卷号	9 期号:3 页码:14
关键词	Cu(II) catalyst Langlois reagent trifluoromethylation indole radical reaction
ISSN号	2073-4344
DOI	10.3390/catal9030278
通讯作者	Shi, Dayong(shidayong@qdio.ac.cn)
英文摘要	This paper offers an efficient copper-catalyzed oxidative trifluoromethylation of indoles with low-cost CF3SO2Na via C-H activation. Notably, the use of a base is crucial for the trifluoromethylation of indoles. This reaction proceeds efficiently in good to excellent yields and is tolerance of a broad range of functional groups. Furthermore, melatonin, a medicine for sleep disorders, is converted to its 2-CF3 analogue in 68% yield. Studies of possible reaction pathways suggest that this reaction proceeds through a radical process.
资助项目	National Natural Science Foundation of China[81773586] ; National Natural Science Foundation of China[81703354] ; Key research and development project of Shandong province[2016GSF201193] ; Key research and development project of Shandong province[2016ZDJS07A13] ; Key research and development project of Shandong province[2016GSF115002] ; Key research and development project of Shandong province[2016GSF115009] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014] ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026] ; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722] ; National Program for Support of Top-notch Young Professionals ; Taishan scholar Youth Project of Shandong province
WOS研究方向	Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000465012800058
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/161095]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Shi, Dayong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266000, Shandong, Peoples R China 3.Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Shi, Xiaolin,Li, Xiaowei,Ma, Lina,et al. Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base[J]. CATALYSTS,2019,9(3):14.
APA	Shi, Xiaolin,Li, Xiaowei,Ma, Lina,&Shi, Dayong.(2019).Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base.CATALYSTS,9(3),14.
MLA	Shi, Xiaolin,et al."Cu(II)-Catalyzed Oxidative Trifluoromethylation of Indoles with KF as the Base".CATALYSTS 9.3(2019):14.